Short oestrous cycles in sheep during anoestrus involve defects in progesterone biosynthesis and luteal neovascularisation

Reproduction : the Official Journal of the Society for the Study of Fertility
H M BrownR J Scaramuzzi

Abstract

Anoestrous ewes can be induced to ovulate by the socio-sexual, 'ram effect'. However, in some ewes, the induced ovulation is followed by an abnormally short luteal phase causing a so-called 'short cycle'. The defect responsible for this luteal dysfunction has not been identified. In this study, we investigated ovarian and uterine factors implicated in male-induced short cycles in anoestrous ewes using a combined endocrine and molecular strategy. Before ovulation, we were able to detect a moderate loss of thecal expression of steroid acute regulatory protein (STAR) in ewes that had not received progesterone priming (which prevents short cycles). At and following ovulation, we were able to identify a significant loss of expression of genes coding key proteins involved in the biosynthesis of progesterone (STAR, CYP11A1 and HSD3B1 (HSD3B)) as well as genes coding proteins critical for vascular development during early luteal development (VEGFA and KDR (VEGFR2)), suggesting dysfunction in at least two pathways critical for normal luteal function. Furthermore, these changes were associated with a significant reduction of progesterone production and luteal weight. Additionally, we cast doubt on the proposed uterus-mediated effect of p...Continue Reading

References

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Jul 23, 2013·The Journal of Clinical Investigation·Alison S CareSarah A Robertson

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Citations

Jul 27, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Achraf AdibMaria-Teresa Pellicer-Rubio
Apr 1, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Claude Fabre-NysRex J Scaramuzzi
Apr 20, 2019·Reproduction in Domestic Animals = Zuchthygiene·Liangyuan LiGuoqing Shi
Feb 6, 2021·The Veterinary Clinics of North America. Food Animal Practice·Hayder Mohammed Hassan Habeeb, Michelle Anne Kutzler

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