Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Brandon D SwanWarren M Grill

Abstract

We conducted intraoperative measurements of tremor during DBS containing short pauses (⩽50 ms) to determine if there is a minimum pause duration that preserves tremor suppression. Nine subjects with ET and thalamic DBS participated during IPG replacement surgery. Patterns of DBS included regular 130 Hz stimulation interrupted by 0, 15, 25 or 50 ms pauses. The same patterns were applied to a model of the thalamic network to quantify effects of pauses on activity of model neurons. All patterns of DBS decreased tremor relative to 'off'. Patterns with pauses generated less tremor reduction than regular high frequency DBS. The model revealed that rhythmic burst-driver inputs to thalamus were masked during DBS, but pauses in stimulation allowed propagation of bursting activity. The mean firing rate of bursting-type model neurons as well as the firing pattern entropy of model neurons were both strongly correlated with tremor power across stimulation conditions. The temporal pattern of stimulation influences the efficacy of thalamic DBS. Pauses in stimulation resulted in decreased tremor suppression indicating that masking of pathological bursting is a mechanism of thalamic DBS for tremor. Pauses in stimulation decreased the efficacy o...Continue Reading

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Citations

Dec 8, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·John-Stuart Brittain
Jun 13, 2018·Journal of Neural Engineering·Guosheng Yi, Warren M Grill
Jan 6, 2017·Science Translational Medicine·David T BrockerWarren M Grill
Jun 5, 2018·Current Behavioral Neuroscience Reports·John-Stuart Brittain, Hayriye Cagnan
Sep 24, 2020·Journal of Neurophysiology·Edward M BelloMatthew D Johnson
Mar 25, 2019·Current Opinion in Biomedical Engineering·Warren M Grill

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