PMID: 16637291Apr 28, 2006Paper

Short peptide fragments with antiulcer activity from a collagen hydrolysate

Bioorganicheskaia khimiia
Iu A ZolotarevN F Miasoedov

Abstract

A peptide acidic hydrolysate of collagen (PHC) was obtained under conditions (4 N HCl) ensuring the predominant formation of short peptides, glyprolines. They were separated and their antiulcer activity was studied. Thirty individual peptides with molecular masses of 174-420 amu were isolated from the PHC by HPLC. The PHC was shown to predominantly contain 2- to 4-aa peptides, including PG, GP, and PGP. Experiments on rats demonstrated that, on intragastric administration at a dose of 1 mg/kg, PHC enhances the stability of the gastric mucosa to the action of ulcerogenic factors, such as ethanol and stress, and exhibits a protecting antiulcer effect. Even a lesser dose (0.1 mg/kg), which reduced ulcer area twofold, was effective in the stress model of ulcer formation. The intraperitoneal and intragastric administration of PHC at a dose of 1 mg/kg was found to exhibit a therapeutic effect in the acetate model of ulcer formation.

References

May 29, 2000·Pathophysiology : the Official Journal of the International Society for Pathophysiology·G SamoninaI Ashmarin
Aug 11, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·L A LyapinaI P Ashmarin
Jul 9, 2002·Pathophysiology : the Official Journal of the International Society for Pathophysiology·G SamoninaL Lyapina
Apr 20, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·I P AshmarinN F Myasoedov

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