PMID: 9524507Apr 3, 1998Paper

Short periods of oscillating fluid pressure directed at a titanium-bone interface in rabbits lead to bone lysis

Acta Orthopaedica Scandinavica
H M Van der VisC J Van Noorden

Abstract

Fluctuating high fluid pressures have been reported in pseudojoints after total hip arthroplasty, and may be present throughout the effective joint space. When the pressure extends locally to the bone implant interface, we hypothesized that it might have led to bone resorption. We developed an experimental implant model to study whether oscillating fluid pressure, applied during 2 hours a day, can lead to osteolysis at the bone implant interface. 12 mature rabbits received a titanium implant, which was allowed to osseointegrate. Thereafter, fluid pressure was applied to a specific area of the titanium bone interface at the periosteal side of the cortex in 6 of the rabbits. The pressure, applied during 2 hours a day for 14 days, oscillated between 70 and 150 mm Hg, with a frequency of 0.1 Hz. Bone resorption was not found in any of the control animals, but it occurred under 4 implants exposed to fluid pressure (p = 0.03; Fisher's exact test). Localized osteolytic lesions had developed, with evidence of osteocyte death in the surrounding cortical bone. In 1 of the 2 specimens without osteolysis, there was evidence of fluid leakage into the soft tissues. In 4 specimens (3 with and 1 without osteolysis), bone formation was observed...Continue Reading

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Citations

Sep 1, 2005·International Orthopaedics·O RahbekK Søballe
May 21, 1999·Acta histochemica·H M Van der VisC J Van Noorden
Jan 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E G LoboaD R Carter
Mar 11, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Lars JohanssonPer Aspenberg
Dec 31, 2011·Journal of Biomechanical Engineering·Hamidreza AlidoustiNeil W Bressloff
Oct 10, 2009·Orthopedic Reviews·Sköldenberg OlofBodén Henrik
Apr 14, 2009·The Journal of Arthroplasty·Cara C PowersCharles A Engh
Jun 17, 2008·The Journal of Arthroplasty·Won Yong ShonJun Gyu Moon
Oct 9, 2007·The Journal of Arthroplasty·Kentaro IseTakashi Nakamura
May 6, 2015·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Redmer van WijngaardenDaniel Haverkamp
Mar 14, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Kenneth A Mann, Mark A Miller
Jun 6, 2006·Acta Orthopaedica·Mikael SundfeldtChristina Gretzer
Aug 5, 2003·Clinical Orthopaedics and Related Research·Satoshi TakayanagiKenji Takagishi
Feb 19, 2016·The Journal of Bone and Joint Surgery. American Volume·Jacob ElkinsWilliam Lack
Dec 22, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Caroline S M HoendersMarja J A van Luyn
Apr 3, 1998·Acta Orthopaedica Scandinavica·P Aspenberg, H van der Vis
Dec 12, 2012·International Journal of Biometeorology·B F Khasanov
Jun 21, 2019·Annals of Biomedical Engineering·Sarah AdamsEda Yildirim-Ayan
Nov 1, 2000·The Journal of Bone and Joint Surgery. American Volume·J P Garino
Nov 1, 2000·The Journal of Bone and Joint Surgery. American Volume·B Mjöberg
Nov 1, 2000·The Journal of Bone and Joint Surgery. American Volume·L SedelP Bizot
Aug 20, 2010·Acta Orthopaedica·Anna FahlgrenPer Aspenberg
Dec 1, 2001·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·J B MatthewsE Ingham
Jan 6, 2000·Acta Orthopaedica Scandinavica·T F LiY T Konttinen
Dec 7, 2019·Journal of Clinical Medicine·Stuart B Goodman, Jiri Gallo
Dec 4, 2002·Clinical Orthopaedics and Related Research·Michael T ManleyAvram A Edidin

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