Short predictable stress promotes resistance to anxiety behavior and increases dendritic spines in prefrontal cortex and hippocampus.

Brain Research
Silvana Regina de MeloBryan Kolb

Abstract

Some stress paradigms have shown protective effects of stress, suggesting increased resilience. Here we investigated whether a short predictable psychological stress, continuous or discontinuous, has a protective or negative long-lasting effect on behavior and cerebral morphology, and if there is difference when stress is experienced at different phases of neurodevelopment, namely in juvenile, adolescent, and adult rats. Male and female rats were stressed on an elevated open platform at different ages (P23, P40, P75), and behavior was assessed later around 90 days of age. Behavioral analysis included measures of anxiety-like behavior, motor activity, and contextual memory. We also investigated the cerebral morphology by using dendritic spine analysis in pyramidal cells, in medial prefrontal cortex (Cg3), orbital prefrontal (AID) and hippocampal region CA1 as well as granule cells in the dentate gyrus (DG) of the hippocampus. Our results showed that short predictable psychological stress, continuous or discontinuous for 12 days, altered emotional behavior and neuronal morphology. Both behavioral and morphological results were sexually dimorphic and suggest a habituation and protective effect, as seen in the decrease of the anxie...Continue Reading

References

Feb 1, 1991·Physiology & Behavior·A L Johnston, S E File
Jan 1, 1996·Physiology & Behavior·V LuineB S McEwen
Apr 8, 1998·Journal of Neuroscience Methods·R Gibb, B Kolb
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·B CzéhE Fuchs
Jul 22, 2004·Journal of Neurobiology·Susan C Cook, Cara L Wellman
Nov 18, 2004·The International Journal of Neuropsychopharmacology·Avi Avital, Gal Richter-Levin
Sep 10, 2005·Behavioural Brain Research·J D StoreyD J K Balfour
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Conor ListonBruce S McEwen
Nov 1, 2006·CNS & Neurological Disorders Drug Targets·J Douglas Bremner
Jun 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tak Pan WongYu Tian Wang
Sep 4, 2007·Progress in Brain Research·Tibor HajszanCsaba Leranth
Sep 22, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Adi MazorHagit Cohen
May 21, 2009·Nature Reviews. Neuroscience·Amy F T Arnsten
May 21, 2009·Nature Reviews. Neuroscience·Adriana FederDennis S Charney
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eunice Y YuenZhen Yan
Dec 17, 2009·Molecular Psychiatry·V K PariharA K Shetty
Apr 27, 2011·Journal of Neurochemistry·Wei-Li ZhuLin Lu
Mar 13, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lin SuoLin Lu
Oct 17, 2013·Toxicologic Pathology·Noel Downes, Pamela Mullins
Mar 22, 2014·Brain and Behavior·Nichola M BrydgesJeremy Hall
Jun 17, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bruce S McEwenJason D Gray
Sep 26, 2015·Nature Neuroscience·Sumantra ChattarjiMohammed Mostafizur Rahman
Dec 25, 2015·Data in Brief·Simon DucharmeUNKNOWN Brain Development Cooperative Group
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Nim Tottenham, Adriana Galván
Jul 25, 2019·Stress : the International Journal on the Biology of Stress·Firdaus S Dhabhar

❮ Previous
Next ❯

Citations

Mar 12, 2021·Biological Psychiatry·Wen-Hua ZhangBing-Xing Pan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.