PMID: 2510164Nov 1, 1989Paper

Short-range genetic structure of Drosophila melanogaster populations in an Afrotropical urban area and its significance

Proceedings of the National Academy of Sciences of the United States of America
J VouidibioJ David

Abstract

Alcohol dehydrogenase (Adh) (alcohol:NAD+ oxidoreductase, EC 1.1.1.1) gene frequencies and ethanol tolerance in Drosophila melanogaster are known to exhibit long-range latitudinal variations on different continents; this has led to the argument that the clines are adaptive. Accordingly, tropical populations are characterized both by a low frequency of Adh-F and by a low ethanol tolerance. In the urban area of Brazzaville (Congo) under an equatorial African climate, an original genetic structure of local populations has been found: Adh-F frequency varies from 3% to 90% when countryside and brewery populations are compared. This variation is accompanied by an increase of ethanol tolerance (from 6% to 13% alcohol). Such differences, which have remained stable for the past 3 years, were observed between collection sites less than 1 km apart. Two other enzyme loci exhibited a correlated variation with Adh-F--i.e., an increase of the S allele of glycerol-3-phosphate dehydrogenase (NAD+) (sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase, EC 1.1.1.8) and of the F allele of glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate:NADP+ 1-oxidoreductase, EC 1.1.1.49). Such observations suggest very strong selective pressures exerted by envi...Continue Reading

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Citations

Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·G K Chambers
Jun 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·B W GeerS W McKechnie
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S R'KhaJ R David
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M ChakirJ R David
May 7, 2013·Annual Review of Neuroscience·Anita V Devineni, Ulrike Heberlein
Sep 5, 2006·Genetics·John E Pool, Charles F Aquadro
Sep 19, 2000·Journal of Neurogenetics·T ShiraiwaT Yamazaki
Mar 14, 2020·The Journal of Experimental Biology·Flora BorneVirginie Courtier-Orgogozo
Apr 1, 1996·Evolution; International Journal of Organic Evolution·Mohamed ChakirJean R David
Mar 18, 2021·Proceedings. Biological Sciences·Flora BorneVirginie Courtier-Orgogozo

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