Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults

Frontiers in Physiology
Diego Montiel RojasFawzi Kadi

Abstract

The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. A total of 1,221 adults (65-79 years) were recruited from five European countries within the framework of NU-AGE study. The physical functioning construct was based on the 36-item Short Form Health Survey. Handgrip strength was used as a single indicator of muscle function and LTL was assessed using quantitative real-time PCR. Women had significantly longer (p < 0.05) LTL than men. Participants in Poland had significantly shorter LTL than in the other study centers, whereas participants in the Netherlands had significantly longer LTL than most of the other centers (p < 0.01). An analysis of LTL as a continuous outcome against physical functioning by using linear models revealed inconsistent findings. In contrast, based on an analysis of contrasting telomere lengths (first vs. fifth quintile of LTL), a significant odds ratio (OR) of 1.7 (95% CI: 1.1 - 2.6; p < 0.05) of having functional limitation was observed in those belonging to the first LTL quintile compared to th...Continue Reading

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT01754012

Software Mentioned

SPSS

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