Short telomere subtelomeric hypomethylation is associated with telomere attrition in elderly diabetic patients 1

Canadian Journal of Physiology and Pharmacology
Naoki MakinoNobuyuki Abe

Abstract

Telomere shortening is well known to be associated with the aging process and aging-associated diseases, including diabetes. The telomere length and subtelomeric methylation status in peripheral leucocytes (LTL) were compared in elderly type 2 diabetes (T2D) patients and diabetes-free controls (C). The methylation status was analyzed between MspI-TRF lengths and HpaII-TRF lengths by using methylation-sensitive and -insensitive restriction enzyme isoschizomers, MspI and HpaII, respectively. The mean telomere lengths, MspI-TRF or HpaII-TRF, were not significantly different between C and T2D patients. The percentage of fractionated densitometry showed that long and middle telomeres (>9.4 kb, 4.4-9.4 kb) were unaltered but short telomeres (<4.4 kb) in T2D patients were increased compared with C group. The methylation status revealed subtelomeric hypomethylation in short telomeres of T2D patients. When some patients with T2D were treated with 3-hydroxy-3-methylglutaril coenzyme A (HMG-CoA) reductase inhibitors (statin), results seen in short telomere of T2D patients were not observed and were not different from C. This suggested that this altered subtelomeric hypomethylation may be associated with the accelerated telomere shortening...Continue Reading

References

May 31, 1990·Nature·C B HarleyC W Greider
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·R S HansenS M Gartler
Nov 28, 2000·Annual Review of Genetics·M J McEachernE H Blackburn
Feb 22, 2003·Nucleic Acids Research·H CherifC N Hales
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Apr 27, 2005·Circulation·Jeffrey P GardnerAbraham Aviv
Aug 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·A AdaikalakoteswariV Mohan
Jan 16, 2007·Atherosclerosis·Antonysunil AdaikalakoteswariViswanathan Mohan
Jan 24, 2007·Nature Genetics·Roberta BenettiMaría A Blasco
Jun 28, 2007·Molecular and Cellular Biochemistry·Jing Zhi GuanNaoki Makino
Feb 19, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Toyoki MaedaNaoki Makino
Mar 26, 2009·Pharmacology & Therapeutics·Andrew LudmanDerek J Hausenloy
May 6, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Toyoki MaedaNaoki Makino
Jun 9, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Toyoki MaedaNaoki Makino
Feb 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Jessica L BuxtonAlexandra I F Blakemore
Oct 4, 2011·Atherosclerosis·Sebastien SaliquesMarianne Zeller
Jun 12, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Virginia BoccardiGiuseppe Paolisso
Dec 21, 2013·Diabetes·Cathy E Elks, Robert A Scott

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Citations

Aug 28, 2020·European Journal of Clinical Investigation·Nooshin MohammadzadehAmirhossein Sahebkar
Apr 24, 2020·Scientific Reports·Harald ManggeWilfried Renner

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