Short Telomeres: Cause and Consequence in Liver Disease.

Seminars in Liver Disease
Daniel D Penrice, Douglas A Simonetto

Abstract

Short telomere syndrome is a genetically inherited syndrome resulting in premature telomere shortening. This premature shortening of telomeres can result in hematologic, pulmonary, vascular, gastrointestinal, and hepatic manifestations of disease. Identifying patients with short telomere syndrome can be a clinical challenge due to the multitude of potential manifestations and lack of widely available diagnostic tests. In this review, we will highlight hepatic manifestations of short telomere syndrome with a focus on diagnosis, testing, and potential treatments.

References

Feb 1, 1990·Molecular and Cellular Biology·T de LangeH E Varmus
Aug 30, 1990·Nature·N D HastieR C Allshire
Apr 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M GreeveT L Wright
Oct 1, 1996·Liver·Y UrabeT Tsuji
Apr 25, 2000·Experimental Cell Research·H AikataT Ide
Sep 27, 2001·Cell·E H Blackburn
Jun 28, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stefanie U WiemannK Lenhard Rudolph
May 22, 2003·Digestive Diseases and Sciences·Sabahattin KaymakogluAtilla Okten
Jun 12, 2003·JAMA : the Journal of the American Medical Association·Jeanne M Clark, Anna Mae Diehl
Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ande SatyanarayanaK Lenhard Rudolph
Apr 16, 2005·American Journal of Medical Genetics. Part a·Muriel GirardEmmanuel Jacquemin
May 26, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alyssa M KrasinskasSusan C Abraham
Jul 12, 2005·Molecular and Cellular Endocrinology·Sharyn Bayne, Jun-Ping Liu
Apr 5, 2007·Nature Protocols·Gabriela M BaerlocherPeter M Lansdorp
Sep 22, 2007·Nature Reviews. Molecular Cell Biology·Eric Gilson, Vincent Géli
Feb 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Andrew MitchellLuc Delriviere
Aug 6, 2008·Annual Review of Genetics·Wilhelm Palm, Titia de Lange
Mar 14, 2009·Blood·Blanche P AlterPhilip S Rosenberg
Dec 17, 2009·The New England Journal of Medicine·Rodrigo T Calado, Neal S Young
Aug 27, 2010·Journal of Hepatology·Matthew HoareGraeme Alexander
Apr 27, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel HartmannK Lenhard Rudolph
Apr 17, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Suman VermaGraeme J M Alexander
Oct 10, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lucia CarulliFabio Nascimbeni
Nov 13, 2012·Journal of Hepatology·Aloysious AravinthanGraeme Alexander
Jan 3, 2013·Aging Cell·Naudia L JonassaintMary Armanios
May 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Fang WangSherman M Weissman
Mar 29, 2014·British Journal of Haematology·Payal P KhinchaSharon A Savage
Apr 1, 2014·Clinics in Liver Disease·David G Koch, Michael B Fallon
Jun 24, 2014·Nature Reviews. Molecular Cell Biology·Daniel Muñoz-Espín, Manuel Serrano
Sep 28, 2014·Best Practice & Research. Clinical Gastroenterology·Jean-Charles Nault
Oct 8, 2014·Journal of Clinical Gastroenterology·Steven ScaglioneMichael L Volk
May 19, 2016·The New England Journal of Medicine·Danielle M TownsleyNeal S Young
Mar 28, 2017·The Journal of Clinical Investigation·Christina V TheodorisDeepak Srivastava
Apr 14, 2017·The New England Journal of Medicine·Daniel A Kelmenson, Michael Hanley
Dec 23, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Aloysious D Aravinthan, Graeme J Alexander
Feb 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jonathan K AlderMary Armanios
May 15, 2018·Journal of Hepatology·Mrinal M PatnaikDouglas A Simonetto
May 26, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Donghee KimAijaz Ahmed

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