Short-Term Administration of Astaxanthin Attenuates Retinal Changes in Diet-Induced Diabetic Psammomys obesus

Current Eye Research
Basma BaccoucheRafika Ben Chaouacha-Chekir

Abstract

Psammomys obesus is a high-fat diet (HFD)-fed animal model of obesity and type 2 diabetes recently explored as a model of non-proliferative diabetic retinopathy. This study tested the protective effect of the pigment astaxanthin (AST) in the P. obesus diabetic retina. Young adult P. obesus were randomly assigned to two groups. The control group received a normal diet consisting of a plant-based regimen, and the HFD group received an enriched laboratory chow. After 3 months, control and diabetic rodents were administered vehicle or AST, daily for 7 days. Body weight, blood glucose, and plasma pentosidine were assessed. Frozen sections of retinas were immunolabeled for markers of oxidative stress, glial reactivity and retinal ganglion cell bodies, and imaged by confocal microscopy. Retinal tissue from AST-treated control and HFD-diabetic P. obesus showed a greater expression of the antioxidant enzyme heme oxygenase-1 (HO-1). In retinas of HFD-diabetic AST-treated P. obesus, cellular retinaldehyde binding protein and glutamine synthetase in Müller cells were more intense compared to the untreated HFD-diabetic group. HFD-induced diabetes downregulated the expression of glial fibrillary acidic protein in astrocytes, the POU domain p...Continue Reading

References

Nov 1, 1996·The British Journal of Ophthalmology·S YamamotoS Hayasaka
Dec 31, 1997·Obesity Research·G R CollierP Zimmet
Aug 26, 1998·The Journal of Clinical Investigation·A J BarberT W Gardner
Oct 28, 1998·Diabetes Research and Clinical Practice·Y OnoY Tsukada
Jul 27, 2001·International Journal of Experimental Diabetes Research·K R WalderG R Collier
Apr 12, 2002·Journal of Neurochemistry·Yunpeng DuT S Kern
Dec 25, 2003·Diabetes Care·Donald S FongUNKNOWN American Diabetes Association
Jul 24, 2004·Cell Death and Differentiation·S R Farooqui-KabirR J Heads
Aug 25, 2004·Investigative Ophthalmology & Visual Science·Pamela M MartinSylvia B Smith
May 26, 2005·Investigative Ophthalmology & Visual Science·Alistair J BarberSarah K Bronson
Jun 28, 2005·Journal of Substance Abuse Treatment·Jeanne CareyDon C Des Jarlais
Jan 24, 2006·Clinical Genitourinary Cancer·Brian I Rini
Aug 29, 2006·Free Radical Biology & Medicine·María MuriachMaría Miranda
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sei-ichiro TsuchihashiJerzy W Kupiec-Weglinski
Feb 3, 2007·Vision Research·David GaucherSerge Picaud
Jul 21, 2007·Experimental Diabetes Research·Renu A Kowluru, Pooi-See Chan
Dec 7, 2007·Investigative Ophthalmology & Visual Science·Ming-Hui SunYeou-Ping Tsao
Jan 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Su-Yen Goh, Mark E Cooper
Mar 8, 2008·Pharmacological Reviews·Nader G Abraham, Attallah Kappas
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Renu A KowluruDennis L Gierhart
Jul 30, 2008·The European Journal of Neuroscience·Heather D VanGuilderAlistair J Barber
Feb 4, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jean L J M ScheijenCasper G Schalkwijk
Jun 24, 2009·Ophthalmic Research·Abdelrahman Gaber SalmanAhmad Abdelmegid Radwan
Mar 26, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kousuke NodaAli Hafezi-Moghadam
Jun 15, 2010·European Journal of Ophthalmology·Asaad A GhanemLamiaa F Arafa
Aug 20, 2010·British Journal of Pharmacology·D DobererM Bilban
Mar 15, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tounès SaïdiDavid Hicks
May 24, 2011·The Journal of Clinical Endocrinology and Metabolism·Robert H EckelSteven R Smith
Oct 13, 2011·Investigative Ophthalmology & Visual Science·Tounès SaïdiDavid Hicks
Jan 24, 2012·American Journal of Ophthalmology·Eiichi SatoAkitoshi Yoshida
Mar 20, 2012·Investigative Ophthalmology & Visual Science·Hille W van DijkMichael D Abràmoff
May 5, 2012·World Journal of Cardiology·Zeinab HegabMamas A Mamas
Jun 5, 2012·Investigative Ophthalmology & Visual Science·Jiawen FanYaowu Qin
Aug 16, 2012·Methods in Molecular Biology·Nurit KaiserGil Leibowitz
Aug 24, 2012·Cell Biochemistry and Function·Anderson C MarçalCarla R O Carvalho

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Citations

Sep 13, 2019·Journal of Diabetes Research·Olvera-Montaño CeciliaRodríguez-Carrizalez Adolfo Daniel
Apr 8, 2020·Oxidative Medicine and Cellular Longevity·Ricardo Raúl Robles-RiveraAdolfo Daniel Rodríguez-Carrizalez
Jan 1, 2020·Food Science & Nutrition·Maha Benlarbi-Ben KhedherRafika Ben Chaouacha-Chekir
Jun 6, 2020·Dose-response : a Publication of International Hormesis Society·Weihong FengYang Mi
Sep 10, 2019·Progress in Retinal and Eye Research·Daniela M VerraDavid Hicks
Feb 17, 2021·Critical Reviews in Food Science and Nutrition·Osman N KanwuguElena G Kovaleva
Jun 22, 2021·Journal of Diabetes Research·Shani PillarAndrzej Grzybowski
Oct 13, 2021·Molecular Nutrition & Food Research·Vemana GowdKa-Wing Cheng

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