Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children

Critical Care Medicine
E Vincent S FaustinoHeart And Lung Failure-Pediatric INsulin Titration (HALF-PINT) Study Investigators

Abstract

Previous studies report worse short-term outcomes with hypoglycemia in critically ill children. These studies relied on intermittent blood glucose measurements, which may have introduced detection bias. We analyzed data from the Heart And Lung Failure-Pediatric INsulin Titration trial to determine the association of hypoglycemia with adverse short-term outcomes in critically ill children. Nested case-control study. Thirty-five PICUs. A computerized algorithm that guided the timing of blood glucose measurements and titration of insulin infusion, continuous glucose monitors, and standardized glucose infusion rates were used to minimize hypoglycemia. Nondiabetic children with cardiovascular and/or respiratory failure and hyperglycemia. Cases were children with any hypoglycemia (blood glucose < 60 mg/dL), whereas controls were children without hypoglycemia. Each case was matched with up to four unique controls according to age group, study day, and severity of illness. None. A total of 112 (16.0%) of 698 children who received the Heart And Lung Failure-Pediatric INsulin Titration protocol developed hypoglycemia, including 25 (3.6%) who developed severe hypoglycemia (blood glucose < 40 mg/dL). Of these, 110 cases were matched to 427...Continue Reading

References

Jul 1, 1992·The Journal of Pediatrics·D H Fiser
May 1, 1996·Critical Care Medicine·M M PollackU E Ruttimann
Dec 1, 1998·JAMA : the Journal of the American Medical Association·J Zhang, K F Yu
Dec 24, 2005·Critical Care Medicine·Titia M VriesendorpJoost B L Hoekstra
May 23, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Eliotte HirshbergHeather Van Duker
Oct 30, 2009·Journal of Diabetes Science and Technology·Garry M SteilMichael S D Agus
Nov 3, 2009·Intensive Care Medicine·Ursula G KyleLarry S Jefferson
Feb 24, 2010·Mayo Clinic Proceedings·Moritoki EgiMichael Bailey
Apr 17, 2010·American Journal of Respiratory and Critical Care Medicine·Marc G JeschkeDavid N Herndon
Jul 14, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Edward Vincent S Faustino, Clifford W Bogue
Jul 14, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Alyssa J RakeChristopher J L Newth
Apr 12, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kristin L OgnibeneKatherine V Biagas
Dec 23, 2011·Critical Care : the Official Journal of the Critical Care Forum·Simon Finfer
Mar 10, 2012·Journal of Diabetes Science and Technology·E Vincent S FaustinoClifford W Bogue
Aug 30, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Heitor Pons LeiteWerther Brunow de Carvalho
Sep 11, 2012·The New England Journal of Medicine·Michael S D AgusUNKNOWN SPECS Study Investigators
Sep 21, 2012·The New England Journal of Medicine·Simon FinferBruce G Robinson
Dec 20, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Tsultem D BhutiaSushil K Kabra
Dec 26, 2013·Critical Care Medicine·Marc G JeschkeRobert Kraft
Jan 10, 2014·The New England Journal of Medicine·Duncan MacraeUNKNOWN CHiP Investigators
May 2, 2014·Pediatric Diabetes·Vijay Srinivasan, Michael S D Agus
Jan 7, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Song LouWarwick Butt
Jan 25, 2017·The New England Journal of Medicine·Michael S D AgusUNKNOWN HALF-PINT Study Investigators and the PALISI Network
Mar 5, 2018·Critical Care : the Official Journal of the Critical Care Forum·Lvlin ChenAndrew Faramand

❮ Previous
Next ❯

Citations

Feb 8, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissPierre Tissieres
Nov 13, 2020·Advances in Nutrition·Elizabeth LedgerRobert H J Bandsma
Dec 21, 2019·The Journal of Thoracic and Cardiovascular Surgery·Nathalie RoyPedro J Del Nido
Apr 20, 2021·Frontiers in Pediatrics·Shereen A MohamedRemon M Yousef

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Michael Sd AgusHALF-PINT Study Investigators and the PALISI Network
Journal of Burn Care & Research : Official Publication of the American Burn Association
Chaitanya K DahagamCharles E Wade
JPEN. Journal of Parenteral and Enteral Nutrition
Heitor Pons LeiteWerther Brunow de Carvalho
© 2022 Meta ULC. All rights reserved