Abstract
Aldosterone controls extracellular volume and blood pressure by regulating Na(+) reabsorption across epithelial cells of the aldosterone-sensitive distal nephron (ASDN). This effect is mediated by a coordinate action on the luminal channel ENaC (generally rate limiting) and the basolateral Na,K-ATPase. Long-term effects of aldosterone (starting within 3 to 6 hours and increasing over days) are mediated by the direct and indirect induction of stable elements of the Na(+) transport machinery (e.g., Na,K-ATPase alpha subunit), whereas short-term effects appear to be mediated by the upregulation of short-lived elements of the machinery (e.g., ENaC alpha subunit) and of regulatory proteins, such as the serum- and glucocorticoid-regulated kinase SGK1. We have recently shown that in cortical collecting duct (CCD) from adrenalectomized (ADX) rats, the increase in Na,K-ATPase activity (approximately threefold in 3 h), induced by a single aldosterone injection, can be fully accounted for by the increase in Na,K-ATPase cell-surface expression. Using the model cell line mpkCCD(cl4), we showed that the parallel increase in Na,K-ATPase function [assessed by Na(+) pump current (I(p)) measurements] and cell-surface expression depends on transc...Continue Reading
References
Sep 1, 1989·Molecular Endocrinology·F VerreyB C Rossier
Oct 1, 1983·Pflügers Archiv : European journal of physiology·G El Mernissi, A Doucet
Apr 1, 1980·Pflügers Archiv : European journal of physiology·M HorsterU Schmidt
Dec 1, 1981·The Journal of Clinical Investigation·K J PettyD Marver
May 1, 1994·The American Journal of Physiology·J Beron, F Verrey
Apr 1, 1993·Molecular and Cellular Biology·M K WebsterG L Firestone
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S WaldeggerF Lang
Jul 1, 1997·Pflügers Archiv : European journal of physiology·B SpindlerF Verrey
Dec 8, 1998·Molecular Biology of the Cell·L MastroberardinoF Verrey
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S Y ChenD Pearce
Apr 7, 1999·The Biochemical Journal·T Kobayashi, P Cohen
Jun 5, 1999·The EMBO Journal·J ParkB A Hemmings
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E KamyninaO Staub
Feb 17, 2001·Molecular Biology of the Cell·S GoninE Féraille
Mar 16, 2001·American Journal of Physiology. Renal Physiology·J LoffingF Verrey
Aug 10, 2001·Current Opinion in Nephrology and Hypertension·J LoffingF Verrey
Oct 13, 2001·The Journal of Biological Chemistry·V SummaE Féraille
Dec 18, 2001·The EMBO Journal·C DebonnevilleO Staub
Mar 7, 2002·American Journal of Physiology. Renal Physiology·James D Stockand
Apr 19, 2002·Steroids·Ralf M LöselMartin Wehling
May 1, 2002·The Journal of General Physiology·Diego Alvarez de la RosaCecilia M Canessa
Citations
Aug 29, 2006·Pflügers Archiv : European journal of physiology·M BensA Vandewalle
Oct 8, 2008·Pflügers Archiv : European journal of physiology·Wen-Hui Wang, Gerhard Giebisch
Dec 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anikó Náray-Fejes-TóthGéza Fejes-Tóth
Sep 23, 2011·Cornea·Shin Hatou
Jul 6, 2010·Current Opinion in Nephrology and Hypertension·Wen-Hui WangDao-Hong Lin
Jan 17, 2008·Clinical and Experimental Pharmacology & Physiology·Il-Ha LeeAnuwat Dinudom
Jan 30, 2007·Cephalalgia : an International Journal of Headache·S ScarroneM Balestrino
Jan 22, 2011·Acta Physiologica·A T UmbachF Lang
Sep 20, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark W MuschEugene B Chang
Nov 1, 2011·Clinical and Experimental Nephrology·Florian Lang, Volker Vallon
May 16, 2012·Molecular Membrane Biology·Jan WilmesFlorian Lang
Jan 26, 2010·Expert Opinion on Drug Safety·Pantelis A SarafidisAnastasios N Lasaridis
Mar 15, 2006·Seminars in Nephrology·David J Rozansky
Sep 16, 2014·The Biochemical Journal·Hao LiuFeifan Guo
Aug 16, 2016·International Journal of Molecular Sciences·Yiyun LouFan Jin
Dec 25, 2003·The Journal of Physiology·Vanessa SummaFrançois Verrey
Mar 28, 2017·The Journal of Endocrinology·Shigeru Shibata
Dec 14, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James D Stockand
Nov 3, 2005·Physiological Genomics·Satyanarayana R PondugulaDaniel C Marcus
Jul 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ciprian SanduFlorian Lang
Nov 2, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rexhep RexhepajFlorian Lang
Oct 4, 2006·Physiological Reviews·Florian LangVolker Vallon
Oct 12, 2004·The Journal of Pharmacology and Experimental Therapeutics·Lihong ChenKathleen K Brown
Aug 20, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Viet D DangAbdel A Alli
Nov 22, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yiyun LouFan Jin
Mar 18, 2006·Endocrinology·Francine E Brennan, Peter J Fuller
Sep 5, 2008·American Journal of Physiology. Renal Physiology·Ferruh ArtuncFlorian Lang
Jul 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Volker VallonFlorian Lang
Jan 10, 2019·Clinical Science·Osamu YamazakiShigeru Shibata
Oct 19, 2010·Biochemical and Biophysical Research Communications·Mentor SopjaniFlorian Lang
May 17, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marcello Camici