PMID: 12763889May 24, 2003Paper

Short-term aldosterone action on Na,K-ATPase surface expression: role of aldosterone-induced SGK1?

Annals of the New York Academy of Sciences
F VerreyMarija Zecevic

Abstract

Aldosterone controls extracellular volume and blood pressure by regulating Na(+) reabsorption across epithelial cells of the aldosterone-sensitive distal nephron (ASDN). This effect is mediated by a coordinate action on the luminal channel ENaC (generally rate limiting) and the basolateral Na,K-ATPase. Long-term effects of aldosterone (starting within 3 to 6 hours and increasing over days) are mediated by the direct and indirect induction of stable elements of the Na(+) transport machinery (e.g., Na,K-ATPase alpha subunit), whereas short-term effects appear to be mediated by the upregulation of short-lived elements of the machinery (e.g., ENaC alpha subunit) and of regulatory proteins, such as the serum- and glucocorticoid-regulated kinase SGK1. We have recently shown that in cortical collecting duct (CCD) from adrenalectomized (ADX) rats, the increase in Na,K-ATPase activity (approximately threefold in 3 h), induced by a single aldosterone injection, can be fully accounted for by the increase in Na,K-ATPase cell-surface expression. Using the model cell line mpkCCD(cl4), we showed that the parallel increase in Na,K-ATPase function [assessed by Na(+) pump current (I(p)) measurements] and cell-surface expression depends on transc...Continue Reading

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Citations

Aug 29, 2006·Pflügers Archiv : European journal of physiology·M BensA Vandewalle
Oct 8, 2008·Pflügers Archiv : European journal of physiology·Wen-Hui Wang, Gerhard Giebisch
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May 17, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marcello Camici

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