Short-term and long-term fracture prediction by bone mass measurements: a prospective study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
C HuangR D Wasnich

Abstract

Prospective and cross-sectional studies have demonstrated that bone mass predicts fracture risk. However, most prospective studies have been limited to a few years of follow-up. We investigated the long-term associations of bone mass with vertebral fractures using longitudinal data collected from more than 500 postmenopausal Japanese-American women in the Hawaii Osteoporosis Study. New vertebral fractures were identified during an average of 2.7 years between 1992 and 1995. Short-term fracture prediction was evaluated using bone mass (spine, calcaneus, distal radius, and proximal radius) measured at the beginning of follow-up. Long-term prediction was evaluated using bone mass measured before the follow-up period (11 years earlier for nonspine bone mass and 8 years earlier for spine). All four bone mass measurements were significant predictors of vertebral fractures identified during the subsequent 2.7 years (short-term prediction), with odds ratios (ORs) ranging from 1.5 to 1.9. The ORs for long-term prediction were slightly lower in magnitude, but the confidence intervals overlapped the short-term ORs considerably, suggesting that both long-term and short-term associations are similar in magnitude. Furthermore, cross-sectiona...Continue Reading

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Citations

Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D P KielL A Cupples
Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eva-Maria LochmüllerFelix Eckstein
Jun 29, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Frederick HoovenEvan Benjamin
Jul 14, 2010·International Journal of Clinical Rheumatology·Bonny L SpeckerEric P Smith
Jun 23, 2004·Maturitas·Mary E ElliottJane E Mahoney
Jun 24, 2005·The Journal of Pediatrics·Bonny L Specker, Eckhard Schoenau
Aug 15, 2003·Clinics in Geriatric Medicine·Paul D Miller
Apr 30, 2008·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Didier B HansE Michael Lewiecki
May 31, 2015·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Theresa MayesRichard J Kagan
May 8, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bonny Specker, Teresa Binkley
Jun 9, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Olof JohnellAlan Tenenhouse
Nov 11, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Katie L StoneUNKNOWN Osteoporotic Fractures Research Group
Mar 6, 2003·Medicine and Science in Sports and Exercise·Gail A GreendaleBarbara Sternfeld
May 19, 2006·Hormone Research·Laura K Bachrach

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