Nov 1, 1989

Short-term and long-term memory deficit following intracarotid Amytal injection: further support for the memory consolidation hypothesis

Brain and Cognition
I RouleauN Giard

Abstract

To test the three main hypotheses of the human amnesic syndrome (encoding, consolidation, retrieval), we designed an original protocol for memory assessment under Amytal that included, in addition to a retrograde memory measure, both short-term and long-term anterograde memory measures. Twenty epileptic patients with SEEG-confirmed unilateral temporal lobe foci were given right and left injections on successive days. Only the long-term memory measure for material presented under Amytal was significantly related to the presence of a temporal contralateral epileptogenic focus, even if it was assessed when the hemisphere had completely recovered from the effect of Amytal. Short-term memory deficits were observed equally often after injections ipsilateral and contralateral to the epileptogenic focus, and no retrograde amnesia was observed. These results are consistent with the consolidation hypothesis.

  • References20
  • Citations4

References

Mentioned in this Paper

Mammillary Body Structure
Immediate Recall
Thalamic Nuclei
Pattern Recognition, Visual
Epilepsy
Hemispheric Specialization
Malignant Neoplasm of Temporal Lobe
Brain
Memory for Designs Test
Entire Temporal Lobe

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