Short-term and long-term outcomes of liver transplantation using moderately and severely steatotic donor livers: A systematic review

Medicine
Chenjiao WuChengfu Xu

Abstract

The aim of this study was to perform a systemic review of the studies addressing the use of moderately and severely steatotic donor livers for liver transplantation. We searched the following electronic databases from January 1, 1989, to August 1, 2017: PubMed, EMBASE, Science Citation Index Expanded, and the Cochrane Library. In addition, reference lists were scanned to identify any additional reports. The quality of published papers was assessed. The main outcomes of the use of moderately and severely steatotic donor livers for liver transplantation, including primary nonfunction, short-term mortality, and long-term mortality, were extracted for pooled analysis. Literature searches identified 16 studies that met the inclusion criteria. There were no randomized controlled studies, and all of the studies were retrospective or prospective case series. From a total of 3226 subjects (532 moderately and severely steatotic donor livers and 2694 controls), we found a significant increase in primary nonfunction [odds ratio (OR): 2.47, 95% confidence interval (95% CI): 1.44-4.27], and a trend of increase in 1-month patient mortality (OR: 1.90, 95% CI: 0.98-3.71) with the use of moderately and severely steatotic donor livers, whereas th...Continue Reading

References

Dec 1, 1993·Transplantation·R S MarkinB W Shaw
Jan 1, 1996·Journal of Hepatology·F TrevisaniD H Van Thiel
Jul 27, 1997·Transplantation·T M FishbeinP A Sheiner
Feb 11, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A M SeifalianB R Davidson
Dec 5, 1998·Transplantation Proceedings·A K ChuiA G Sheil
Dec 5, 1998·Transplantation Proceedings·M A UreñaR Gómez Sanz
Mar 20, 1999·Transplantation Proceedings·L De CarlisD Forti
Mar 20, 1999·Transplantation Proceedings·R CaneloB Ringe
Mar 20, 1999·Transplantation Proceedings·K F YoongP McMaster
Oct 9, 1999·Transplantation·A M SeifalianB R Davidson
Dec 20, 2000·Transplantation Proceedings·A K ChuiA G Sheil
Apr 12, 2001·Seminars in Liver Disease·M Selzner, P A Clavien
May 13, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Deborah VerranGeoffery McCaughan
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Leticia FernándezCarmen Peralta
Apr 12, 2005·The Journal of Surgical Research·Paolo CaraceniMauro Bernardi
Aug 9, 2005·Journal of Hepatology·Esther Carrasco-ChaumelCarmen Peralta
Sep 19, 2006·Transplantation Proceedings·C H D KwonS K Lee
Jan 2, 2007·Annals of Surgery·Reeta VeteläinenThomas M van Gulik
May 26, 2007·Transplantation Proceedings·S NikeghbalianS A Malek-Hosseini
Nov 29, 2007·Annals of Surgery·Lucas McCormackPierre-Alain Clavien
Dec 25, 2007·American Journal of Surgery·Martin K AngeleFlorian Loehe
May 30, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Chengfu XuYouming Li
Nov 19, 2008·Journal of Hepatology·Jian-Gao Fan, Geoffrey C Farrell
Dec 26, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Javier BriceñoPedro López-Cillero
Mar 21, 2009·Transplantation·Huda M NoujaimTercio Genzini
Nov 3, 2009·Clinical Transplantation·Umberto BaccaraniFabrizio Bresadola
Nov 18, 2009·Transplantation Proceedings·J LiF-G Li
May 19, 2010·World Journal of Gastroenterology : WJG·Chao-Hui YuYou-Ming Li
Jul 21, 2010·Archives of Surgery·M B Majella DoyleWilliam C Chapman
Dec 15, 2010·Journal of Hepatology·Lucas McCormackPierre-Alain Clavien
May 26, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jan P DerooseIan P J Alwayn
Jul 26, 2011·American Journal of Surgery·Maximilian von HeesenMohammed Reza Moussavian
Apr 2, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sangbin HanJaewon Joh
Apr 29, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael J J ChuAdam S J R Bartlett
Oct 23, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francesco TandoiRenato Romagnoli
Jun 18, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Adam DoyleNazia Selzner

❮ Previous
Next ❯

Citations

Feb 18, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Marjolein van ReevenRobert J Porte
Apr 3, 2020·Journal of Clinical Medicine·Caroline JadlowiecTimucin Taner
May 13, 2021·Clinics in Liver Disease·Akshata MogheNaudia Jonassaint
Oct 1, 2021·Pediatric Transplantation·Joshua W PurvisJayme E Locke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved