Short-term antihypertensive medication does not exacerbate sleep-disordered breathing in newly diagnosed hypertensive patients

American Journal of Hypertension
P R BartelS Rossouw

Abstract

It has been speculated for some time that various antihypertensive medications may have a deleterious effect on respiration during sleep and thereby enhance the apparent association between hypertension and sleep apnea/hypopnea (SAH). However, there are few data to support this contention. The present study used a double-blind, randomized, cross-over design to contrast the effects of 6 weeks treatment with alpha-methyldopa and the combination of hydrochlorothiazide and amiloride with that of amlodipine and the combined diuretics in a group of 24 newly diagnosed patients with primary hypertension. All-night polysomnography was performed before the initiation of therapy (baseline) and at the end of the two treatment periods. Respiratory variables failed to reveal any significant differences between the treatments and baseline, or between the two different treatment regimens. The two treatment regimens achieved similar reductions in blood pressure. The prevalence of SAH was 25% before treatment, which is comparable to a prevalence of 20% in a similar group drawn from the same population but receiving various antihypertensive medications. The findings of this study are in agreement with previous reports using other classes of antih...Continue Reading

Citations

May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J M SametN M Punjabi
Nov 18, 2017·International Journal of Hypertension·Masood AhmadSana Akbar
Jan 9, 2009·Journal of Human Hypertension·J-P BaguetJ-L Pépin
Nov 29, 2001·Journal of Hypertension·A G LoganT D Bradley
Oct 3, 2002·The Journal of Cardiovascular Nursing·Kathy C RichardsCorey L Nagel
May 23, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuomi Kario
Jun 4, 2013·The Cochrane Database of Systematic Reviews·Martina MasonIan Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.