PMID: 7088265Apr 1, 1982Paper

Short-term behavioural effects of neurohypophyseal hormones: pharmacological characteristics

G Meisenberg


Neurohypophyseal hormones and related peptides cause behavioural alterations after intracerebroventricular injection in mice. In the present study, these effects, consisting of excessive grooming and scratching, and of escape-directed activity in stressful situations, could easily be distinguished from those of other centrally acting peptides and drugs by means of two different behavioural bioassays. The effects were not antagonized by drugs that block cholinergic or adrenergic receptors, but they were powerfully suppressed by some potent psychotropic agents. Some compounds with strong vasoconstrictor or vasodilatory actions did not mimick or antagonize the behavioural alterations, suggesting that vasoconstriction is not essential for the induction of these effects. A considerable degree of tolerance could be induced and cross-tolerance was observed between different neurohypophyseal hormones. In rats, behavioural alterations caused by oxytocin and vasopressin could be demonstrated as well, but they were by far less pronounced than those observed in mice. For comparison, some data on the behavioural effects of bombesin are included. This peptide caused behavioural alterations similar to those of the neurohypophyseal hormones, b...Continue Reading


Feb 7, 1977·European Journal of Pharmacology·V M WiegantW H Gispen
Mar 17, 1978·Brain Research·M E Raichle, R L Grubb
Oct 1, 1977·Pharmacology, Biochemistry, and Behavior·H KruseD de Wied
Dec 1, 1978·Pharmacology, Biochemistry, and Behavior·D B RondeauA Barbeau
Dec 7, 1978·Nature·P L HoffmanB Tabakoff
Oct 10, 1975·Brain Research·M L Cohn, M Cohn
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·W A KrivoyS Lande
Mar 1, 1957·British Journal of Pharmacology and Chemotherapy·T J HALEY, W G MCCORMICK


Nov 28, 2007·Archives of Women's Mental Health·E Sibolboro Mezzacappa, J Endicott
Mar 5, 1991·European Journal of Pharmacology·H H Berendsen, C L Broekkamp
Jul 15, 1985·Life Sciences·A CowanD E Gmerek
Oct 5, 1987·Life Sciences·R Arletti, A Bertolini
Mar 1, 1984·Pharmacology, Biochemistry, and Behavior·G MeisenbergM A Collins
Dec 1, 1990·Pharmacology, Biochemistry, and Behavior·G MeisenbergS A Lorens
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·N A Darmani
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·G Meisenberg, W H Simmons
Jan 1, 1983·Pharmacology & Therapeutics·T B van Wimersma GreidanusD de Wied
Jul 15, 1994·Brain Research. Developmental Brain Research·L R NoonanG A Mason
May 1, 1986·Regulatory Peptides·J D CaldwellC A Pedersen
Nov 1, 1983·Peptides·D E Gmerek, A Cowan
Aug 10, 2001·Physiology & Behavior·L A LumleyJ L Meyerhoff
Jul 2, 2003·Regulatory Peptides·Marike LancelInga D Neumann
Jun 12, 1992·Annals of the New York Academy of Sciences·M M McCarthyD W Pfaff
Nov 19, 2002·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·E S MezzacappaEdward S Katkin
Jan 1, 1997·International Journal of Behavioral Medicine·E S Mezzacappa
Apr 4, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dirk ScheeleRené Hurlemann
Jul 13, 2000·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·E S MezzacappaE Bagiella
Oct 1, 1987·Neuropeptides·R Arletti, A Bertolini
Jul 1, 1986·Neuropeptides·J D CaldwellC A Pedersen
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·A Argiolas, G L Gessa
Jul 23, 2013·Pharmacology, Biochemistry, and Behavior·J H BroadbearP Mak
Jan 1, 1988·Annals of the New York Academy of Sciences·A Cowan

Related Concepts

Argipressin Tannate
Behavior, Animal
Drug Interactions
Drug Tolerance
Escape Reaction
Pulmonary Vascular Resistance

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.