Short-term blood pressure variability over 24 h and target organ damage in middle-aged men and women

Journal of Human Hypertension
J M MaddenP M Kearney

Abstract

Blood pressure variability (BPV) has been associated with cardiovascular events; however, the prognostic significance of short-term BPV remains uncertain. As uncertainty also remains as to which measure of variability most accurately describes short-term BPV, this study explores different indices and investigates their relationship with subclinical target organ damage (TOD). We used data from the Mitchelstown Study, a cross-sectional study of Irish adults aged 47-73 years (n=2047). A subsample (1207) underwent 24-h ambulatory BP monitoring (ABPM). As measures of short-term BPV, we estimated the s.d., weighted s.d. (wSD), coefficient of variation (CV) and average real variability (ARV). TOD was documented by microalbuminuria and electrocardiogram (ECG) left ventricular hypertrophy (LVH). There was no association found between any measure of BPV and LVH in both unadjusted and fully adjusted logistic regression models. Similar analysis found that ARV (24 h, day and night), s.d. (day and night) and wSD were all univariately associated with microalbuminuria and remained associated after adjustment for age, gender, smoking, body mass index (BMI), diabetes and antihypertensive treatment. However, when the models were further adjusted ...Continue Reading

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Citations

Mar 24, 2016·Current Hypertension Reports·Maria-Cláudia IrigoyenFernanda Marciano Consolim-Colombo
Feb 12, 2017·Emerging Themes in Epidemiology·Jamie M MaddenAnthony P Fitzgerald
Jan 31, 2018·Statistics in Medicine·J M MaddenA P Fitzgerald
Feb 25, 2018·Aging Clinical and Experimental Research·Arianna MoranoMario Bo
Oct 21, 2017·Journal of the American Heart Association·Luis J MenaGladys E Maestre
Oct 17, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph C WatsoWilliam B Farquhar
Jun 10, 2020·Journal of Hypertension·Tan Lai ZhouCoen D A Stehouwer
Aug 14, 2019·Nutrients·Joseph C Watso, William B Farquhar
Nov 23, 2020·The Journal of Clinical Hypertension·Ming-Hui HungJaw-Wen Chen

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