Short-term caloric restriction exerts neuroprotective effects following mild traumatic brain injury by promoting autophagy and inhibiting astrocyte activation

Behavioural Brain Research
Yuan LiuLina Ma

Abstract

Cognitive deficits may occur after mild traumatic brain injury (mTBI), but effective treatment modalities are presently unavailable. Caloric restriction (CR) has beneficial effects on neurodegenerative diseases and brain injury. However, the underlying mechanisms have not yet been clearly defined. Therefore, the aim of the present study was to investigate the short-term effects of CR treatment on cognitive function in mice after mTBI. Forty-five 12-week-old C57/BL6 mice were subjected to closed-head mTBI using a weight drop device. The mice were then randomly divided into three groups according to their diet for 30 days: the normal calorie group (mTBI+NC group, n=15), the caloric restriction group (mTBI+CR group, n=15), and the high energy group (mTBI+HE group, n=15). After 30 days, the Morris water maze test was performed to evaluate learning abilities. Nissl staining, immunohistochemistry, and western blotting were used to monitor pathological changes and changes in autophagy-associated proteins in the hippocampus. The average escape latency was significantly shorter in the mTBI+CR group than in the mTBI+NC and mTBI+HE groups, and the number of target platform crossings in the mTBI+CR group was significantly higher than in th...Continue Reading

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Citations

Sep 13, 2019·Journal of Cellular Physiology·Zhiqing ZengHongtao Qu
May 5, 2020·Journal of Diabetes and Metabolic Disorders·Ali Tootee, Bagher Larijani
May 22, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Mir Bahram SafariMohsen Naseri
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Jul 27, 2021·BMJ Nutrition, Prevention & Health·Yixuan FangJianrong Wang
Oct 28, 2021·Aging Cell·Jiawei QianJianrong Wang

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