Short-term calorie restriction enhances skeletal muscle stem cell function.

Cell Stem Cell
Massimiliano CerlettiAmy J Wagers

Abstract

Calorie restriction (CR) extends life span and ameliorates age-related pathologies in most species studied, yet the mechanisms underlying these effects remain unclear. Using mouse skeletal muscle as a model, we show that CR acts in part by enhancing the function of tissue-specific stem cells. Even short-term CR significantly enhanced stem cell availability and activity in the muscle of young and old animals, in concert with an increase in mitochondrial abundance and induction of conserved metabolic and longevity regulators. Moreover, CR enhanced endogenous muscle repair and CR initiated in either donor or recipient animals improved the contribution of donor cells to regenerating muscle after transplant. These studies indicate that metabolic factors play a critical role in regulating stem cell function and that this regulation can influence the efficacy of recovery from injury and the engraftment of transplanted cells.

References

Mar 1, 1989·The Biochemical Journal·H S Baht, E D Saggerson
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Haihong ZongGerald I Shulman
Jan 15, 2003·Annual Review of Medicine·Stephen D HurstingJ Carl Barrett
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·A MAURO
Sep 6, 2005·Science·Didier MontarrasMargaret Buckingham
Nov 9, 2005·Circulation·Ismayil AhmetMark Talan
Mar 10, 2007·The EMBO Journal·Zachary Gerhart-HinesPere Puigserver
Mar 16, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lisa D MarroquinYvonne Will
Jun 2, 2007·Cell·Shihuan KuangMichael A Rudnicki
Aug 9, 2007·Nature Reviews. Molecular Cell Biology·Steven J Russell, C Ronald Kahn
Feb 26, 2008·Cell·Derrick J RossiIrving L Weissman
Sep 11, 2008·International Journal of Biological Sciences·Kristi Muldoon JacobsDavid Gius
Feb 11, 2009·Cold Spring Harbor Symposia on Quantitative Biology·M CerlettiA J Wagers
Dec 17, 2009·Trends in Endocrinology and Metabolism : TEM·Rozalyn M Anderson, Richard Weindruch
Jan 19, 2010·Nature Cell Biology·Aaron W B JoeFabio M V Rossi
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tim J SchulzYu-Hua Tseng
Aug 11, 2011·Development·John J McCarthyCharlotte A Peterson
Oct 1, 2011·Cold Spring Harbor Symposia on Quantitative Biology·Y C JangA J Wagers
Dec 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Simone HettmerAmy J Wagers

❮ Previous
Next ❯

Citations

Oct 8, 2013·Trends in Cell Biology·David VilchezAndrew Dillin
Jan 15, 2014·The Proceedings of the Nutrition Society·Colin Selman
Aug 8, 2014·Nature Medicine·Juhyun OhAmy J Wagers
Jun 8, 2013·Free Radical Biology & Medicine·Michael E WalshHolly Van Remmen
May 30, 2013·Development·Ng Shyh-ChangLewis C Cantley
Oct 5, 2013·Disease Models & Mechanisms·Fabio DemontisNorbert Perrimon
Nov 28, 2013·Cancer & Metabolism·Stephen D HurstingLaura M Lashinger
Oct 19, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·James G Ryall
Oct 30, 2015·International Journal of Molecular Sciences·Maximina H Yun
Feb 24, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nuredin BakhtiariAmin Tashakor
Feb 7, 2015·Cell Stem Cell·Alberto Diaz-RuizRafael de Cabo
Feb 7, 2016·Seminars in Cell & Developmental Biology·Jason Chua Min-WenNg Shyh-Chang
Jan 20, 2016·Skeletal Muscle·Andrew S Brack, Pura Muñoz-Cánoves
Oct 16, 2015·Experimental Cell Research·Simone HettmerAmy J Wagers
Feb 28, 2016·Molecular Aspects of Medicine·Pedro Sousa-Victor, Pura Muñoz-Cánoves
Mar 10, 2016·Nature Reviews. Molecular Cell Biology·Albert E Almada, Amy J Wagers
Sep 5, 2014·Cell Metabolism·Clifford D L Folmes, Andre Terzic
Jun 19, 2013·The European Journal of Neuroscience·June-Hee ParkGrigori Enikolopov
Mar 5, 2013·The FEBS Journal·Laura García-PratPura Muñoz-Cánoves
Sep 30, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael Hadjiargyrou, Regis J O'Keefe
Apr 5, 2014·Journal of Internal Medicine·R J BurgessS J Morrison
Jun 12, 2013·Cell·Carlos López-OtínGuido Kroemer
Jun 19, 2015·Aging Cell·Matthew J LayeDaniel E L Promislow
Oct 21, 2014·Journal of Neurochemistry·Jill Bouchard, Saul A Villeda
Dec 8, 2014·Ageing Research Reviews·Tytus Murphy, Sandrine Thuret
Sep 11, 2012·Current Opinion in Cell Biology·José M P Freije, Carlos López-Otín
Jun 6, 2015·Cell Stem Cell·Peter D AdamsK Lenhard Rudolph
Jun 6, 2015·Cell Stem Cell·Lorenz StuderDaniela Cornacchia
Apr 15, 2014·Cell Metabolism·Kristopher BurkewitzWilliam B Mair
Apr 15, 2015·Trends in Endocrinology and Metabolism : TEM·Pedro Sousa-VictorPura Muñoz-Cánoves
Nov 12, 2013·Experimental Gerontology·Gianluigi MazzoccoliManlio Vinciguerra
Feb 12, 2013·Cell Metabolism·Clifford D L FolmesAndre Terzic
Jun 2, 2014·Current Opinion in Pharmacology·Adam P LightfootAnne McArdle
Mar 13, 2014·Cell Stem Cell·Maria M MihaylovaÖmer H Yilmaz
Nov 6, 2012·Cell Stem Cell·Clifford D L FolmesAndre Terzic
Feb 12, 2013·Cell Stem Cell·Robert A J Signer, Sean J Morrison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.