PMID: 8953555Dec 1, 1996Paper

Short-term canine implantation of a glucose monitoring-telemetry device

Medical Engineering & Physics
P AtanasovE Wilkins

Abstract

In this study we report the development and short-term in vivo evaluation of an integrated implantable device consisting of an amperometric glucose biosensor, a miniature potentiostat, a FM signal transmitter, and power supply. The device (dimensions: 5.0 x 7.0 x 1.5 cm) was implanted under the skin of medium-size anaesthetized dog. The experimental set-up included several methods for data collection: analog recording via wired X-T chart recorders; data collection by wearable microprocessor--data logger, and remote data collection via antenna and receiver linked to a computer-based data acquisition system. The device (sensor) performance was evaluated in vitro prior to implantation, using different model solutions simulating the physiological environment. A linear response to glucose concentration was obtained up to 25 mM glucose, with a sensitivity of 0.5 microA/mM. The results of short-term subcutaneous implantation of the integrated device reveal adequate monitoring of an artificially-induced glycaemia. The delay-time was 3-7 minutes. These tests demonstrate the feasibility of data transmission by the telemetry system through the skin of a medium-sized dog and allow the commencement of chronic in vivo experimentation.

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Citations

Oct 22, 2010·Analytical and Bioanalytical Chemistry·Anthony Guiseppi-Elie
Dec 31, 2010·Applied Microbiology and Biotechnology·Stefanie RubenwolfFelix von Stetten
Dec 26, 2001·Chemical Reviews·G S Wilson, Y Hu

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