Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines

Journal of Adolescent and Young Adult Oncology
Susan C GilchristJose Banchs

Abstract

Studies of cardiac function in adolescent and young adult survivors have been performed at least a decade after anthracycline exposure, with little knowledge of short-term changes in cardiac function in this age group. To this end, we evaluated cardiac function within a 2-year period among 18 patients who received high-dose anthracyclines for osteosarcoma treatment. At 2 years, there was a significant decline in left ventricular ejection fraction (p = 0.005), with 8 of 18 patients having a >10% reduction. There was a significant change in E-wave velocity (p = 0.04). To our knowledge, this is the first study assessing short-term change in systolic and diastolic function in osteosarcoma patients receiving anthracyclines.

References

Mar 19, 2008·Heart·Steven E LipshultzRebecca E Scully
Mar 7, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven E LipshultzTracie L Miller
Jan 7, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangJens-Uwe Voigt

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Citations

Sep 16, 2021·Cancer Medicine·Fei WangEugenie S Kleinerman

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Methods Mentioned

BETA
imaging technique

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