Short-term cold exposure activates TRH neurons exclusively in the hypothalamic paraventricular nucleus and raphe pallidus

Neuroscience Letters
Agustina CabralMario Perello

Abstract

The neuropeptide thyrotropin releasing hormone (TRH) is necessary for adequate cold-induced thermogenesis. TRH increases body temperature via both neuroendocrine and autonomic mechanisms. TRH neurons of the hypothalamic paraventricular nucleus (PVN) regulate thermogenesis through the activation of the hypothalamic-pituitary-thyroid axis during cold exposure. However, little is known about the role that TRH neurons play in mediating the sympathetic response to cold exposure. Here, we examined the response of TRH neurons of rats to cold exposure in hypothalamic regions including the PVN, the dorsomedial nucleus and the lateral hypothalamus along with areas of the ventral medulla including raphe obscurus, raphe pallidus (RPa) and parapyramidal regions. Our results using a double immunohistochemistry protocol to identify TRH and c-Fos (as a marker of cellular activity) followed by analysis of preproTRH gene expression demonstrate that only TRH neurons located in the PVN and the RPa are activated in animals exposed to short-term cold conditions.

References

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Citations

Mar 19, 2014·Cell Metabolism·Shaun F MorrisonDomenico Tupone
Jun 13, 2015·PLoS Genetics·Julia JaroslawskaLeslie P Kozak
Feb 13, 2018·Journal of Molecular Endocrinology·K Alexander IwenGeorg Brabant
Nov 15, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Beatriz de Carvalho BorgesLucila Leico Kagohara Elias
Nov 25, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ngoc Ly T NguyenTimothy J Bartness
Oct 11, 2015·The European Journal of Neuroscience·Gothje LautenschlägerHeidrun H Krämer
Nov 8, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Kerstin Krause
Dec 24, 2018·European Thyroid Journal·Zhi ZhangEric Fliers
Mar 30, 2021·European Thyroid Journal·Lisa Volke, Kerstin Krause

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