Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans.

Cell Metabolism
J. R. DalenbergDana M Small

Abstract

There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no- or low-calorie "diet" drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose-sweetened beverages with, but not without, a carbohydrate over 10 days decreases insulin sensitivity in healthy human participants, an effect that correlates with reductions in midbrain, insular, and cingulate responses to sweet, but not sour, salty, or savory, taste as assessed with fMRI. Taste perception was unaltered and consuming the carbohydrate alone had no effect. These findings indicate that consumption of sucralose in the presence of a carbohydrate rapidly impairs glucose metabolism and results in longer-term decreases in brain, but not perceptual sensitivity to sweet taste, suggesting dysregulation of gut-brain control of glucose metabolism.

References

Jun 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Y LiangE F Pfeiffer
Jul 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Y LiangE F Pfeiffer
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
Jul 7, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I M BairdG Hildick-Smith
Dec 4, 2003·Journal of the American Dietetic Association·V Lee GrotzF Xavier Pi-Sunyer
Apr 28, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T L Davidson, S E Swithers
Jul 6, 2004·Physiology & Behavior·L M BartoshukJ M Weiffenbach
Dec 29, 2006·Diabetes Care·Muhammad A Abdul-GhaniRalph A DeFronzo
May 15, 2007·The Journal of Physiology·Oliver J MaceGeorge L Kellett
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Robert F MargolskeeSoraya P Shirazi-Beechey
Mar 28, 2008·Neuron·Ivan E de AraujoSidney A Simon
Apr 9, 2008·Annual Review of Nutrition·George L KellettArmelle Leturque
Apr 11, 2008·Annals of the New York Academy of Sciences·B J CaseyTodd A Hare
Jul 21, 2009·The European Journal of Neuroscience·Genevieve BenderDana M Small
Oct 8, 2009·Diabetes Care·Rebecca J BrownKristina I Rother
Apr 28, 2010·The British Journal of Nutrition·Jing MaChristopher K Rayner
Jun 1, 2010·Brain Structure & Function·Dana M Small
Jan 25, 2011·The British Journal of Nutrition·Robert E SteinertChristoph Beglinger
Jul 5, 2011·Cell Metabolism·Gerald J Taborsky
Jul 5, 2011·Cell Metabolism·Rayner Rodriguez-DiazAlejandro Caicedo
Oct 11, 2011·Journal of Cognitive Neuroscience·Aaron J NewmanMichael T Ullman
Dec 14, 2011·The American Journal of Clinical Nutrition·Tongzhi WuChristopher K Rayner
Aug 3, 2012·The American Journal of Clinical Nutrition·Allison C SylvetskyMiriam B Vos
Oct 12, 2012·Social Cognitive and Affective Neuroscience·Kathryn L MillsSarah-Jayne Blakemore
May 2, 2013·Diabetes Care·M Yanina PepinoSamuel Klein
May 7, 2013·Current Biology : CB·Ivan E de AraujoDana M Small

❮ Previous
Next ❯

Citations

Sep 17, 2020·The American Journal of Clinical Nutrition·Tauseef A Khan, John L Sievenpiper
Mar 24, 2020·Nature Reviews. Endocrinology·Claire Greenhill
Aug 9, 2020·Frontiers in Endocrinology·Eleonora MoriconiMassimiliano Caprio
Aug 21, 2020·BMC Medicine·Hubert KolbStephan Martin
Oct 7, 2020·Nutrients·Maria MirabelliAntonio Brunetti
Feb 14, 2021·Comprehensive Reviews in Food Science and Food Safety·Margaux R Mora, Robin Dando
Jan 26, 2021·Frontiers in Nutrition·Michelle D PangEllen E Blaak
Feb 5, 2021·Frontiers in Nutrition·Juan Carlos BórquezRoberto Bravo-Sagua
Mar 27, 2021·Journal of the American College of Cardiology·Filippa JuulNiyati Parekh
May 5, 2021·Advances in Nutrition·Filippa JuulNiyati Parekh
Jun 22, 2021·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·Inayara Beatriz Araujo MartinsRosires Deliza
Jul 31, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Colby J VorlandDavid B Allison
Sep 25, 2021·Biomédica : revista del Instituto Nacional de Salud·Jorge Alberto EscotoRoxana Valdés-Ramos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.