Short-Term Curcumin Gavage Sensitizes Insulin Signaling in Dexamethasone-Treated C57BL/6 Mice

The Journal of Nutrition
Lili TianTianru Jin

Abstract

Long-term dietary curcumin (>12 wk) improves metabolic homeostasis in obese mice by sensitizing insulin signaling and reducing hepatic gluconeogenesis. Whether these occur only secondary to its chronic anti-inflammatory and antioxidative functions is unknown. In this study, we assessed the insulin sensitization effect of short-term curcumin gavage in a rapid dexamethasone-induced insulin resistance mouse model, in which the chronic anti-inflammatory function is eliminated. Six-week-old male C57BL/6 mice received an intraperitoneal injection of dexamethasone (100 mg/kg body weight) or phosphate-buffered saline every day for 5 d, with or without simultaneous curcumin gavage (500 mg/kg body weight). On day 7, insulin tolerance tests were performed. After a booster dexamethasone injection and curcumin gavage on day 8, blood glucose and insulin concentrations were measured. Liver tissues were collected on day 10 for quantitative polymerase chain reaction and Western blotting to assess gluconeogenic gene expression, insulin signaling, and the expression of fibroblast growth factor 21 (FGF21). Primary hepatocytes from separate, untreated C57BL/6 mice were used for testing the in vitro effect of curcumin treatment. Dexamethasone inject...Continue Reading

References

Aug 1, 1992·The Journal of Clinical Investigation·A OgawaR H Unger
Nov 2, 2004·Nature Reviews. Immunology·Paul J Coffer, Boudewijn M T Burgering
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
May 3, 2005·Biological & Pharmaceutical Bulletin·Minpei KurodaMikio Kitahara
May 20, 2005·The Journal of Clinical Investigation·Alexei KharitonenkovArmen B Shanafelt
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
May 13, 2008·The American Journal of Clinical Nutrition·Minghua TangMichael Liebman
Oct 23, 2008·Metabolism: Clinical and Experimental·Eun-Mi JangMi-Kyung Lee
Jan 23, 2009·American Journal of Physiology. Endocrinology and Metabolism·Alex RafachoJosé R Bosqueiro
Oct 13, 2010·Nutrition Journal·Jennie WickenbergJoanna Hlebowicz
Nov 26, 2010·Nutrition Reviews·Lini Alappat, Atif B Awad
Dec 3, 2010·The Journal of Clinical Investigation·Rucha PatelCarolyn L Cummins
Jul 10, 2012·Diabetes Care·Somlak ChuengsamarnSiwanon Jirawatnotai
Sep 13, 2012·American Journal of Physiology. Endocrinology and Metabolism·Wilfred IpTianru Jin
Oct 25, 2012·The Journal of Clinical Investigation·Heather A Ferris, C Ronald Kahn
Dec 26, 2012·Diabetes & Metabolism·K GarianiF R Jornayvaz
Jan 23, 2013·BioFactors·Subash C GuptaBharat B Aggarwal
Sep 18, 2013·Biochemical and Biophysical Research Communications·Kook Hwan KimMyung-Shik Lee
Oct 10, 2014·The Journal of Endocrinology·Michael RouseJosephine M Egan
Dec 17, 2014·Molecular Endocrinology·Rucha PatelCarolyn L Cummins
Apr 22, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·William W DuBurton B Yang

❮ Previous
Next ❯

Citations

Apr 5, 2016·Biochimie·Leesha K GunninkLarry L Louters
Jun 12, 2016·Journal of Diabetes·Lili Tian, Tianru Jin
Oct 11, 2017·Journal of Molecular Cell Biology·Kejing ZengTianru Jin
Mar 16, 2018·Acta Pharmacologica Sinica·Tian-Ru Jin
Sep 2, 2016·Hormone Molecular Biology and Clinical Investigation·Albert Pérez-MartíJoana Relat
Jan 8, 2020·Nutrients·Danja J Den HartoghEvangelia Tsiani
Jun 11, 2016·Hormone Molecular Biology and Clinical Investigation·Anjeza Erickson, Régis Moreau
Dec 12, 2017·Food & Function·Mariana de AlmeidaCiomar Aparecida Bersani-Amado
Jan 1, 2021·Critical Reviews in Clinical Laboratory Sciences·Yasaman Badakhshi, Tianru Jin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.