Short-term desensitization of phosphatidylinositol turnover via muscarinic acetylcholine receptors and histamine H1-receptors in smooth muscle

Biochemical and Biophysical Research Communications
S Hishinuma, M K Uchida

Abstract

Smooth muscle of guinea-pig taenia caecum was desensitized by treatment with 10(-4)M carbachol or 10(-4)M histamine for 30 min in Ca-free solution containing 2mM EGTA. Phosphatidylinositol turnover stimulated by carbachol was not reduced by desensitization with either carbachol or histamine, while the turnover stimulated by histamine was reduced by desensitization with histamine, but not with carbachol. These results are consistent with our previous report (1) that heterologous desensitization induced by carbachol occurs at intracellular Ca stores and homologous desensitization by histamine occurs at H1 receptors.

References

Mar 25, 1975·Biochimica Et Biophysica Acta·R H Michell
Feb 13, 1987·Biochemical and Biophysical Research Communications·A K HoJ H Wang
Dec 1, 1987·British Journal of Pharmacology·S Hishinuma, M K Uchida
Jan 15, 1987·Biochemical and Biophysical Research Communications·M Iino
Aug 1, 1974·Japanese Journal of Pharmacology·H OashiT Okada
May 16, 1984·Biochemical and Biophysical Research Communications·A P Dawson, R F Irvine

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Citations

Jan 5, 2007·Clinical and Experimental Pharmacology & Physiology·Shigeru HishinumaMasaki Saito
Aug 2, 2008·Clinical and Experimental Pharmacology & Physiology·Shigeru Hishinuma, Masaki Saito
Jun 1, 1992·Journal of Autonomic Pharmacology·R M EglenR L Whiting

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