Abstract
To determine the tolerance of increasing dosages of an incompletely hydrolysed and/or incompletely absorbed food dextrin coming from wheat starch, NUTRIOSE FB, at daily levels of 10 and 15 g up to 60 and 80 g, respectively. A randomized, double-blind, multiple dose, placebo-controlled, combined crossover and parallel trial. The metabolic ward of TNO Nutrition and Food Research. A total of 20 healthy men (age 31.7 +/- 9.1 y; BMI 24.5 +/- 2.9 kg/m2). One group of 10 subjects consumed on top of their diet 10, 30 and 60 g of NUTRIOSE FB or maltodextrin (placebo) daily. The other group of 10 subjects consumed 15, 45 and 80 g daily. Each dose was consumed for 7 days. Compared with placebo, flatulence occurred more frequently over the last 6 days on 30, 60 or 80 g/day of NUTRIOSE FB (P < 0.05). During the last 24 h, that is, days 6-7, of 60 and 80 g/day of NUTRIOSE FB, the frequency of flatulence was even higher (P < 0.05). During the last 24 h on a daily dose of 60 g NUTRIOSE FB, the frequency of defecation decreased (P < 0.05). Bloating occurred more often during the last 24 h on 80 g/day of NUTRIOSE FB (P < 0.05). None of the doses of NUTRIOSE FB resulted in diarrhoea. Compared to baseline levels, breath H2 excretion, which was onl...Continue Reading
References
Oct 1, 1978·The American Journal of Clinical Nutrition·M J Albrink
Jul 1, 1987·The American Journal of Clinical Nutrition·T Stone-Dorshow, M D Levitt
May 1, 1983·The American Journal of Clinical Nutrition·K H DuncanR L Weinsier
Apr 1, 1995·The American Journal of Clinical Nutrition·B J Rolls
Mar 1, 1994·The American Journal of Clinical Nutrition·I P van MunsterF M Nagengast
Aug 1, 1996·The American Journal of Clinical Nutrition·S R Hertzler, D A Savaiano
Nov 1, 1996·The Proceedings of the Nutrition Society·G R GibsonM D Collins
Aug 1, 1997·Appetite·W J PasmanM S Westerterp-Plantenga
Aug 13, 1998·The American Journal of Clinical Nutrition·J J Rumessen, E Gudmand-Høyer
Jan 23, 1999·The Journal of Nutrition·Y BouhnikJ C Rambaud
Feb 27, 1999·European Journal of Clinical Nutrition·W van DokkumE G van den Heuvel
Jan 6, 2000·Regulatory Toxicology and Pharmacology : RTP·I G Carabin, W G Flamm
Jul 27, 2000·Scandinavian Journal of Gastroenterology·H A KoetseF Stellaard
Feb 24, 2001·Critical Reviews in Food Science and Nutrition·M Roberfroid, J Slavin
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D HansenUNKNOWN STORM Study Group
Mar 16, 2002·The British Journal of Nutrition·S SinauM Vermorel
Jan 28, 2003·European Journal of Clinical Nutrition·A Ruskoné-FourmestrauxY Bouhnik
Citations
Aug 17, 2004·European Journal of Nutrition·M VermorelY Rayssiguier
Apr 2, 2008·The British Journal of Nutrition·Pascale RozanMarie-Hélène Saniez
Feb 17, 2006·European Journal of Clinical Nutrition·W PasmanA Kardinaal
Aug 25, 2007·European Journal of Clinical Nutrition·A GrysmanT M S Wolever
Jun 24, 2011·Journal of the American College of Nutrition·Julie-Anne NazareMartine Laville
Feb 24, 2009·Critical Reviews in Food Science and Nutrition·Hollie A Grabitske, Joanne L Slavin
Sep 9, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Audrey M Neyrinck, Nathalie M Delzenne
Jan 22, 2010·Annals of Nutrition & Metabolism·Maria L StewartJoanne L Slavin
Nov 10, 2013·PloS One·Mark R HobdenGlenn R Gibson
Sep 26, 2013·Journal of Nutritional Science and Vitaminology·Yuka KishimotoShukuko Ebihara
May 7, 2013·Nutrients·Jackie NoackJoanne Slavin
Feb 8, 2005·European Journal of Nutrition·Ellen G H M van den HeuvelAlwine F M Kardinaal
Dec 18, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Shuguang LiLarry E Miller
Mar 23, 2011·Drug Development and Industrial Pharmacy·S KrenzlinJ Siepmann
Oct 26, 2011·Nutrition Research·Laetitia Guérin-DeremauxLarry E Miller
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Youness KarroutJuergen Siepmann
Jan 13, 2009·International Journal of Pharmaceutics·Youness KarroutJürgen Siepmann
Oct 18, 2008·Journal of the American Dietetic Association·Hollie A Grabitske, Joanne L Slavin
Oct 8, 2008·Molecular Nutrition & Food Research·Maria L StewartJoanne L Slavin
Sep 22, 2011·Molecular Nutrition & Food Research·Carina E P KozmusMaria A Vieira-Coelho
Jan 3, 2013·Phytotherapy Research : PTR·F Di BartolomeoW Van den Ende
Apr 7, 2015·Food Chemistry·Renjusha MenonM S Sajeev
Oct 19, 2016·Digestive Diseases and Sciences·Johnson W McRorie, William D Chey
Mar 3, 2017·Journal of the American Association of Nurse Practitioners·Kellen V Lambeau, Johnson W McRorie
Mar 21, 2012·The Journal of International Medical Research·C Lefranc-MillotM H Saniez-Degrave
Feb 14, 2009·The Journal of International Medical Research·J L SlavinG Fotopoulos
Feb 3, 2011·Nutrition Research and Practice·Laetitia Guerin-DeremauxDaniel Wils
Feb 27, 2018·European Journal of Nutrition·Sevda Gholizadeh ShamasbiMojgan Mirghafourvand
Oct 24, 2018·Journal of the American College of Nutrition·Junaida Astina, Suwimol Sapwarobol
Sep 21, 2010·International Journal of Food Sciences and Nutrition·Philippe MarteauBéatrice Housez
May 20, 2011·International Journal of Food Sciences and Nutrition·Laetitia Guerin-DeremauxLarry E Miller
Apr 20, 2014·The Journal of Nutrition·David J BaerVolker Mai
Nov 26, 2019·Journal of the American Association of Nurse Practitioners·Johnson W McRorieWilliam D Chey
Dec 27, 2018·Alimentary Pharmacology & Therapeutics·Eirini DimidiS Mark Scott
May 30, 2020·Nutrition & Metabolism·Fan HuHongmei Zhang
Nov 5, 2020·Nutrients·Christine H EmilienJames H Hollis
Feb 1, 2020·Cell Host & Microbe·Edward C DeehanJens Walter