PMID: 2493897Feb 4, 1989Paper

Short term effect of captopril on microalbuminuria induced by exercise in normotensive diabetics

BMJ : British Medical Journal
G RomanelliG Giustina

Abstract

To investigate whether captopril has any effect on microalbuminuria induced by exercise in normotensive diabetic patients with early stage nephropathy. Randomised, double blind, crossover trial. Outpatient department. 22 diabetics with stage II nephropathy (urinary albumin excretion rate less than 20 micrograms/min; 15 with type I diabetes and seven with type II), 32 patients with stage III nephropathy (urinary albumin excretion rate 20-200 micrograms/min; 14 with type I diabetes and 18 with type II), and 10 normal subjects. Four exercise tests on a cycle ergometer: the first two under basal conditions and the third and fourth after subjects had received captopril (two 25 mg doses in 24 hours) or placebo (two tablets in 24 hours). Exercised until 90% of maximum heart rate achieved. Mean urinary excretion one hour after the first two exercise tests was 21 micrograms/min in normal subjects, 101 micrograms/min in diabetic patients with stage II nephropathy, and 333 micrograms/min in those with stage III nephropathy. Similar results were obtained after placebo. After captopril the urinary excretion rate one hour after exercise was significantly decreased in diabetics with stage II (36 micrograms/min) and stage III (107 micrograms/m...Continue Reading

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Citations

Jan 1, 1995·Journal of Diabetes and Its Complications·C E Mogensen
Jan 1, 1991·British Journal of Clinical Pharmacology·R J MacFadyenJ L Reid
Dec 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·G F WattsA Polak
Apr 7, 1990·BMJ : British Medical Journal·S BjörckM Aurell
Sep 1, 1994·British Heart Journal·C E Mogensen
Sep 1, 1993·Postgraduate Medical Journal·D BuggyM Walsh
Nov 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J H BauerV Knaus
Apr 1, 1990·The Journal of Diabetic Complications·C K ChristensenC E Mogensen
May 1, 1996·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·F O Karlsson, A J Garber
Jan 1, 1991·Scandinavian Journal of Urology and Nephrology·O TorffvitC D Agardh
Apr 15, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Per Løstrup Poulsen
Apr 15, 2016·American Journal of Physiology. Renal Physiology·Sharon GreenbergAssi Milwidsky
Oct 8, 2020·Reviews in Endocrine & Metabolic Disorders·Francesco TecilazichAndrea Giustina

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