PMID: 9556212Apr 29, 1998Paper

Short-term effect of dexamethasone on fatty acid and cholesterol synthesis in isolated rat hepatocytes

Biochemistry and Molecular Biology International
A M Giudetti, G V Gnoni

Abstract

The short-term effect of dexamethasone, a synthetic glucocorticoid, on both fatty acid and cholesterol synthesis has been investigated in rat hepatocyte cultures. Within 4h following hormone addition to the cultures, a noticeable stimulation of labelled acetate incorporation into fatty acids was observed. Similar behaviour was noticed when [3H]H2O was used as an independent index of the lipogenic activity. In the same cultures, however, cholesterol synthesis from both [14C]acetate or [3H]H2O was significantly reduced by dexamethasone addition. In these conditions, no significative variation of cholesterol synthesis starting from labelled mevalonate was observed.

Citations

Dec 27, 2011·European Journal of Pharmacology·Amany A AbdinAmira A E El-Saadany
Jul 13, 2007·Molecular and Cellular Endocrinology·Alexandros Vegiopoulos, Stephan Herzig
Feb 10, 2009·European Journal of Clinical Investigation·D H van RaalteM Diamant
Aug 5, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Conor P WoodsJeremy W Tomlinson
Oct 21, 2016·Journal of Molecular Endocrinology·Ewa Harasim-SymborAdrian Chabowski

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