Short-Term Effect of Low-Dose, Electromyography-Guided Botulinum Toxin A Injection in the Treatment of Chronic Lateral Epicondylar Tendinopathy: A Randomized, Double-Blinded Study

The Journal of Bone and Joint Surgery. American Volume
Alexandre CreuzéMathieu de Sèze

Abstract

Botulinum toxin A (BoNT-A) is a novel treatment for chronic lateral epicondylar tendinopathy. Preliminary studies have demonstrated promising results; however, confirmation of the effectiveness of BoNT-A treatment and further assessment of its side effects are required. This study investigated the analgesic effects of BoNT-A in the treatment of chronic lateral epicondylar tendinopathy. This was a phase-III, single-center, randomized, double-blinded, placebo-controlled study including 60 patients with chronic lateral epicondylar tendinopathy that had been resistant to treatment for >6 months. Patients received either a 40-IU injection of BoNT-A or saline solution placebo into the extensor carpi radialis brevis (ECRB) muscle, aided by electromyographic (EMG) stimulation. Follow-up was 3 months. The primary assessment criterion was the percentage of patients whose pain was reduced by >50% at 90 days after injection. Secondary outcomes, including pain intensity, pain frequency, interference with quality of life, sick leave taken, maximum grip strength, and side effects, were assessed at days 30 and 90, and the number of participants per group requesting additional therapies at day 90 was recorded. Twenty-nine patients in the BoNT-A...Continue Reading

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Citations

Feb 12, 2020·The American Journal of Sports Medicine·Carlos Alberto Acosta-OlivoMario Simental-Mendía
Oct 19, 2019·The Journal of Bone and Joint Surgery. American Volume·Robert Z Tashjian, Peter N Chalmers
Jun 10, 2020·Current Sports Medicine Reports·Clint MooreBrett Boyce
Jul 4, 2020·American Journal of Physical Medicine & Rehabilitation·Bo SongPrathap Jayaram
Oct 2, 2020·Plastic and Reconstructive Surgery·You J KimKevin C Chung
Dec 18, 2020·Clinics in Shoulder and Elbow·Gyeong Min KimYong-Geun Park
Nov 21, 2020·American Journal of Physical Medicine & Rehabilitation·Bo SongPrathap Jayaram
Aug 4, 2020·Zeitschrift für Orthopädie und Unfallchirurgie·Stephan GrünerMarcela Lippert-Grüner

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