PMID: 6981468Jul 1, 1982Paper

Short-term effect of prednisone on serum 1,25-dihydroxyvitamin D in normal individuals and in hyper- and hypoparathyroidism

Clinical Endocrinology
J J BraunJ C Birkenhäger

Abstract

Oral administration of prednisone (30 mg/day for 9 days) to six normal individuals induced a significant rise in the concentration of serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] within 2 days. In four patients with primary hyperparathyroidism a larger increase of 1,25-(OH)-2D was observed within 3 days. In these patients the 1,25-(OH)-2D concentration remained elevated during the whole period of prednisone administration (10 days) whereas in the control group it had returned to basal levels or below after 9 days of prednisone administration. This response appeared dependent upon parathyroid hormone (PTH) as we found no change in the (basally low) 1,25-(OH)2D concentrations in five patients with hypoparathyroidism during 3-4 days of prednisone administration (30 mg/day). In these patients vitamin D medication had been interrupted 3-5 days before the administration of prednisone, whereafter serum calcium was kept between 2.10 and 2.30 mmol/1 by means of calcium infusion. The response of 1,25-(OH)2D to prednisone is best explained by a stimulatory action of glucocorticoids upon PTH secretion or by the induction of increased PTH sensitivity.

References

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Citations

May 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H K NielsenL Mosekilde
Nov 23, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D ChappardM Audran
Apr 26, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Marie Hélène Lafage-ProustThierry Thomas
Dec 1, 2001·Bone·D PatschanF Buttgereit
Jul 14, 1983·The New England Journal of Medicine·L G Raisz, B E Kream
Sep 1, 1986·Annals of the Rheumatic Diseases·J W BijlsmaO Huber-Bruning
Jan 1, 1989·Clinical Endocrinology·I R Reid
Apr 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S GatesN H Bell
Oct 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Geun-Shik LeeEui-Bae Jeung
Nov 15, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sarah F AndresP Kay Lund
Aug 12, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sylvie HuybersJoost G J Hoenderop

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