Short-term effect of stress on tyrosine hydroxylase activity

Neurochemistry International
K OkaT Nagatsu

Abstract

The short-term influences of stress on the activities of tyrosine hydroxylase in vivo and in vitro were examined in mice. The in vivo tyrosine hydroxylase activity was estimated by the rate of dopa accumulation which was measured at 30 min after the injection of NSD-1015 (100 mg kg), an aromatic l-amino acid decarboxylase inhibitor, intraperitoneally and was compared with tyrosine hydroxylase activity measured in vitro. For the in vivo assay, both the accumulation of dopa (tyrosine hydroxylase activity) and that of 5-hydroxytryptophan (tryptophan hydroxylase activity) and the levels of monoamines and the metabolites (noradrenalin, adrenalin, dopamine, normetanephrine, 3-methoxytyramine and serotonin) and those of precursor amino acids, tyrosine and tryptophan, were investigated in ten different brain regions and in adrenals. The amount of dopa accumulation in the brain as a consequence of decarboxylase inhibition, in vivo tyrosine hydroxylase activity, was significantly increased by stress, in nerve terminals (striatum, limbic brain, hypothalamus, cerebral cortex and cerebellum) and also in adrenals. The effect of stress on tyrosine hydroxylase activity in vitro at a subsaturating concentration of 6-methyltetrahydropterin cofac...Continue Reading

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A GuidottiE Costa
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·W LovenbergI Hanbauer
Jan 1, 1975·Journal of Neural Transmission·M LindqvistA Carlsson
Sep 1, 1985·The Journal of Comparative Neurology·M PiotteJ R Brawer
Jun 1, 1973·The Journal of Pharmacy and Pharmacology·A Carlsson, M Lindqvist
Apr 23, 1974·Biochemical and Biophysical Research Communications·R HoeldtkeS Kaufman
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·V H MorgenrothR H Roth
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P R VullietN Weiner
Feb 1, 1980·Analytical Biochemistry·T Fukushima, J C Nixon

Citations

Feb 1, 1996·Pharmacology, Biochemistry, and Behavior·H MiuraT Nagatsu
Mar 3, 2005·Pharmacology, Biochemistry, and Behavior·A Briones-ArandaO Picazo
Sep 1, 1989·Acta Physiologica Scandinavica·F Chaouloff
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·A Briones-ArandaO Picazo

Related Concepts

5-Hydroxytryptophan
Adrenal Medulla
Brain
Brain Stem
Carboxy-Lyases
Cerebellum
Cerebral Cortex
Corpus Striatum Structure
Dopa
Dopamine

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