PMID: 7400707May 1, 1980Paper

Short-term effect of two pesticides on the survival, ovarian 32P uptake and gonadotrophic potency in a freshwater catfish, Heteropneustes fossilis (Blouch)

The Journal of Endocrinology
H Singh, T P Singh


The effects of pesticides containing either an organophosphate malathion (Cythion) or an organochloride endrin (Hexadrin) on the survival, ovarian 32P uptake and the gonadotrophic potency of the pituitary gland and serum of Heteropneustes fossilis were studied for 96 h. Hexadrin was found to be more toxic than Cythion. Reduced ovarian 32P uptake and a significantly decreased level of total gonadotrophin in the pituitary gland and serum were seen when fish were placed either in a drug concentration that had been found to kill half the fish in 96 h or in a safe concentration of Hexadrin and cythion in aquarium water. Administration of LH or homologous pituitary extract during the exposure of the fish to the pesticides increased the ovarian 32P uptake. The data suggest that these pesticides retarded gonadotrophin secretion which in turn reduced ovarian 32P uptake. However, they did not interfere with the effects of exogenous LH or pituitary extract at the dose levels tested.


Apr 1, 1985·Bulletin of Environmental Contamination and Toxicology·P K Saxena, K Mani
Jul 28, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Andrew Waye, Vance L Trudeau
Jan 1, 1984·Journal of Toxicology and Environmental Health·D M Lechner, M S Abdel-Rahman

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