Short-term effects of a high nitrate diet on nitrate metabolism in healthy individuals

Nutrients
Catherine P BondonnoJonathan M Hodgson

Abstract

Dietary nitrate, through the enterosalivary nitrate-nitrite-NO pathway, can improve blood pressure and arterial stiffness. How long systemic nitrate and nitrite remain elevated following cessation of high nitrate intake is unknown. In 19 healthy men and women, the time for salivary and plasma nitrate and nitrite to return to baseline after 7 days increased nitrate intake from green leafy vegetables was determined. Salivary and plasma nitrate and nitrite was measured at baseline [D0], end of high nitrate diet [D7], day 9 [+2D], day 14 [+7D] and day 21 [+14D]. Urinary nitrite and nitrate was assessed at D7 and +14D. Increased dietary nitrate for 7 days resulted in a more than fourfold increase in saliva and plasma nitrate and nitrite (p < 0.001) measured at [D7]. At [+2D] plasma nitrite and nitrate had returned to baseline while saliva nitrate and nitrite were more than 1.5 times higher than at baseline levels. By [+7D] all metabolites had returned to baseline levels. The pattern of response was similar between men and women. Urinary nitrate and nitrate was sevenfold higher at D7 compared to +14D. These results suggest that daily ingestion of nitrate may be required to maintain the physiological changes associated with high nitra...Continue Reading

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Citations

Mar 4, 2017·Journal of the American College of Cardiology·Andrew M FreemanPenny Kris-Etherton
Apr 2, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Greggory R Davis, David Bellar
Nov 21, 2019·Biological Chemistry·Matthew B AmdahlMark T Gladwin
Aug 8, 2017·Journal of Sports Sciences·Georgina L KentPeter Peeling
Jun 15, 2017·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)Maged Younes
Jun 29, 2018·Environmental Science and Pollution Research International·Shirin HaftbaradaranMohammad Jafar Malakouti
Jun 15, 2017·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)Maged Younes
Sep 6, 2019·Mayo Clinic Proceedings. Innovations, Quality & Outcomes·Vincent A PallazolaFrancine K Welty

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Methods Mentioned

BETA
blood collection

Software Mentioned

SPSS

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