Short-Term Effects of a Multimodal 3-Week Inpatient Pulmonary Rehabilitation Programme for Patients with Sarcoidosis: The ProKaSaRe Study

Respiration; International Review of Thoracic Diseases
Heidrun LingnerKonrad Schultz

Abstract

Real-world data on the effects of a multicomponent pulmonary rehabilitation (PR) for patients with sarcoidosis are scarce. To describe characteristics of patients with sarcoidosis referred for a 3-week inpatient PR, to assess the effects of PR on their quality of life (QoL) and clinical outcomes, and to investigate whether there are specific subgroups who particularly benefit from PR. Using a prospective multicentre study design, data regarding 6-min walking distance (6MWD), QoL (Saint George's Respiratory Questionnaire, SGRQ), and the secondary outcomes of dyspnoea and psychological burden (fatigue, anxiety, and depression) were collected. We included 296 patients in the study (average age 49.1 ± 9.7 years, 47% female, average vital capacity 3.5 ± 1.0 L [87.0 ± 20.6 predicted]). The 6MWD improved by the end of the rehabilitation by 39.8 m on average (p < 0.0001; standardised response mean, SRM = 0.61), SGRQ showed significant improvements in all 3 domains, and the total score (p < 0.001) improved by 5.69-8.28 points (SRM 0.46-0.62). For the secondary outcomes, significant improvement (p < 0.001) was seen for all measured parameters, e.g., dyspnoea (modified Medical Research Council Scale, mMRC), fatigue (Fatigue Assessment Sca...Continue Reading

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Citations

Jun 21, 2019·Current Opinion in Pulmonary Medicine·Jinny Tavee, Daniel Culver
Feb 1, 2020·Expert Review of Respiratory Medicine·W Ennis James, Marc A Judson
Aug 1, 2019·Current Opinion in Pulmonary Medicine·Hilario NunesDominique Valeyre
Aug 3, 2020·Current Opinion in Pulmonary Medicine·Divya C Patel, Dominique Valeyre
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Aug 28, 2020·Journal of Personalized Medicine·Marjolein DrentBert Strookappe
Jul 6, 2019·Nature Reviews. Disease Primers·Johan GrunewaldJoachim Müller-Quernheim
Aug 1, 2019·Current Opinion in Pulmonary Medicine·Jinny Tavee, Daniel Culver
Jan 1, 2020·Chronic Respiratory Disease·Anita GrongstadAnne Edvardsen
May 8, 2021·MMW Fortschritte der Medizin·Inga JaroschAndreas Rembert Koczulla
Mar 5, 2020·Respiration; International Review of Thoracic Diseases·Anita GrongstadAnne Edvardsen
Jun 19, 2021·The European Respiratory Journal·Robert P BaughmanDaniel R Ouellette

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