Short-term effects of a perinatal exposure to the HBCDD α-isomer in rats: Assessment of early motor and sensory development, spontaneous locomotor activity and anxiety in pups

Neurotoxicology and Teratology
Nicolas MauriceHenri Schroeder

Abstract

The present study investigated the developmental neurotoxicity of an early exposure to α-HBCDD through the ingestion of contaminated hen's egg in pregnant and lactating Wistar female rats. Hens were given α-HBCDD-contaminated feed (40 ng/g fresh matter) for 5 and 10 days, which produced eggs with HBCDD content of 33 and 102 ng/glipid weight, respectively. Female rats were administered daily p.o. with an appropriate volume of the whole egg from the day of fertilization (GD0) to the weaning day for pups (PND21). Fetuses and pups were thus exposed continuously to α-HBCDD via the dam over a whole 42-day period that included both gestation and lactation. The administered egg volume was calculated on the basis of daily egg consumption in humans (0.7 egg/person/day) and duration of gestation and lactation in both species, which led animals to be exposed to α-HBCDD at levels of 22 and 66 ng/kg/day, respectively. Neurobehavioral development of pups was investigated from PND3 to PND25 using various tasks including the righting reflex (PND4), the grasping reflex (PND5), the negative geotaxis (PND9), the forelimb grip strength test (PND10) and the locomotor coordination test (PND20). Pup ultrasonic vocalizations were also recorded daily fr...Continue Reading

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Citations

May 5, 2020·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Yisong ZhangJing Shao
Mar 19, 2021·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Christiane Vleminckx
May 14, 2021·Environmental Science. Processes & Impacts·Benjamin Harris, Mohamed Abou-Elwafa Abdallah
May 20, 2021·Journal of Hazardous Materials·Katarzyna JędruchniewiczPatryk Oleszczuk
Jun 11, 2021·Frontiers in Genetics·Sara B FernandesJonathan D Turner

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