Short-term effects of a very-low-protein diet supplemented with ketoacids in nondialyzed chronic kidney disease patients

European Journal of Clinical Nutrition
S F FeitenL Cuppari

Abstract

To evaluate the effects on the nutritional and metabolic parameters of a very-low-protein diet supplemented with ketoacids (VLPD+KA) in comparison with a conventional low-protein diet (LPD) in chronic kidney disease (CKD) patients. Prospective, randomized, controlled clinical study. Outpatient Clinic of the Nephrology Division of Federal University of Sao Paulo, Brazil. The study involved 24 patients with advanced CKD (creatinine clearance <25 ml/min) that were randomly assigned to either a VLPD+KA (VLPD+KA group, 12 patients) or to a conventional LPD with 0.6 g/kg/day (LPD group, 12 patients). The patients were followed for 4 months. Nutritional status was adequately maintained with both diets for the studied period. Protein intake and serum urea nitrogen decreased significantly only in the VLPD+KA group (from 0.68+/-0.17 to 0.43+/-0.12 g/kg/day, P<0.05; from 61.4+/-12.8 to 43.6+/-14.9 mg/dl, P<0.001; respectively). Ionized calcium did not change in the VLPD+KA group but tended to decrease in the LPD group. Serum phosphorus tended to decrease in the VLPD+KA group probably as a result of a significant reduction in dietary phosphorus (529+/-109 to 373+/-125 mg/day, P<0.05) associated to the phosphorus-binding effect of the ketoa...Continue Reading

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Citations

Oct 20, 2009·Nutrition Research Reviews·Caroline Bauchart-ThevretDouglas G Burrin
Oct 12, 2010·Applied and Environmental Microbiology·Felix S KrauseBernhard J Eikmanns
Apr 29, 2011·Obesity Surgery·Amy L LightnerMarc L Melcher
Dec 5, 2009·Clinical and Experimental Nephrology·UNKNOWN Japanese Society of Nephrology
Oct 31, 2013·Applied Microbiology and Biotechnology·Verena Bückle-VallantBernhard J Eikmanns
Feb 27, 2013·Advances in Chronic Kidney Disease·Jerry Yee
Sep 10, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Michel Aparicio
Feb 13, 2008·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Sintra Eyre, Per-Ola Attman
Dec 4, 2012·Microbial Biotechnology·Stefan WieschalkaBernhard J Eikmanns
Mar 15, 2006·Seminars in Nephrology·Lara B PupimT Alp Ikizler
Feb 16, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anuja P ShahJoel D Kopple
Jul 28, 2015·Critical Reviews in Food Science and Nutrition·Yasmine Probst, Gail Zammit
Jul 31, 2016·BMC Nephrology·Claudia D'AlessandroAdamasco Cupisti
Jan 9, 2019·Kidney Research and Clinical Practice·Bancha SatirapojOuppatham Supasyndh
Feb 19, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Hsing-Yu ChenHeng-Chih Pan
Jun 27, 2020·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Fiona N ByrneJoseph Eustace
Apr 4, 2021·Nutrients·Mugurel ApetriiAdrian Covic
Jul 13, 2021·Frontiers in Medicine·Pablo MolinaJuan Jesús Carrero

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