Short term effects of adrenaline in bronchiolitis: a randomised controlled trial

Archives of Disease in Childhood
A Abul-Ainine, D Luyt

Abstract

Airway narrowing in acute bronchiolitis does not respond to inhaled bronchodilators but does to adrenaline when compared to bronchodilators. Influences of supportive care were not considered in previous treatment studies. Short term effects of nebulised adrenaline and saline placebo were compared in infants with moderately severe acute bronchiolitis. Thirty eight infants were recruited, 19 in each treatment group. After stabilisation, infants received a single 3 ml dose of either levo-adrenaline (3 mg) or 0.9% saline placebo via Pari-BABY nebuliser driven with 6 l/min oxygen for three minutes. Changes in respiratory rate (RR), heart rate (HR), oxygen saturation (SpO(2)), Respiratory Distress Assessment Instrument (RDAI), and activity levels were assessed at 20 minutes intervals at times -20, 0, 20, 40, and 60 minutes around treatment. Respiratory virology and chest x ray were performed. Supportive therapy prior to study treatment resulted in significant reductions in RR (by 4.3 breaths/min) and HR (by 4.6 beats/min); there were no changes in SpO(2) or RDAI. There were no further changes in any parameter in either treatment group at any assessment time after treatment. No improvement was shown with inhaled adrenaline in acute br...Continue Reading

References

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Citations

Sep 4, 2004·Indian Journal of Pediatrics·G R Sethi, Gaurav Nagar
Jul 20, 2002·Lancet·J B M van Woensel, W M C van Aalderen
Nov 30, 2002·Paediatric Respiratory Reviews·Gilberto Bueno FischerAlejandro J Colom
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May 10, 2012·Journal of Paediatrics and Child Health·Rashmi Ranjan Das
Sep 12, 2012·Interdisciplinary Perspectives on Infectious Diseases·Michael T Del VecchioJohn P Gaughan
Oct 3, 2003·Expert Opinion on Pharmacotherapy·Simon Broughton, Anne Greenough
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Oct 20, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Semanur KuyucuEsat Yilgor
Mar 7, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Liviana Da DaltEugenio Baraldi
Mar 25, 2018·Emergency Medicine Australasia : EMA·Ed OakleyUNKNOWN Paediatric Research in Emergency Departments International Collaborative (PREDICT)
Apr 17, 2007·CJEM·Lance Brown
Jun 17, 2011·The Cochrane Database of Systematic Reviews·Lisa HartlingRicardo M Fernandes

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