Short-term effects of external and internal biliary drainage on liver and cellular immunity in experimental obstructive jaundice

Journal of Hepato-biliary-pancreatic Surgery
Kei MizuguchiYoshikazu Kuroda

Abstract

The effects of preoperative biliary drainage for obstructive jaundiced patients are controversial. Although experimental studies have proven the benefit of internal biliary drainage (ID) over external biliary drainage (ED), ID has several clinical problems, such as clogging or tube replacement. The aim of this study was to determine whether there were any differences in T-cell function, liver function, and histology, between rats in ID and ED groups in short-term experiments. Following bile duct ligation (BDL) for 14 days, rats in the ED and ID groups had 7 days of ED and 7 days of ID, respectively. Normal rats were used as negative controls (control group). For positive controls, we used a group with BDL and no drainage (BDL group). Serum bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were measured, splenic T-cell proliferation was assayed to check cellular immunity, and liver histology was examined. Recovery of bilirubin and ALT was similar in the ED and ID groups. Recovery of AST was worse in the ID group than in the ED group, but the difference was not statistically significant. Levels of ALP in the BDL and ID groups were significantly higher than those in the con...Continue Reading

Citations

Aug 30, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·N A van der GaagD J Gouma
Nov 29, 2012·The Cancer Journal·Johanna A M G TolDirk J Gouma
Oct 18, 2011·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Seon-Young ParkJong-Sun Rew
Jun 6, 2017·Annals of Surgical Treatment and Research·Xin HuangJia-Hong Dong

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