PMID: 2494371Jan 1, 1989Paper

Short-term effects of fat emulsion on serum lipids in postoperative patients

JPEN. Journal of Parenteral and Enteral Nutrition
M M MeguidM P Akahoshi

Abstract

The effect of short-term infusion of intravenous fat on serum lipids was assessed in 23 patients who had elective cancer operations and were given 20% Intralipid for 5 days postoperatively as part of a standard total parenteral nutrition regimen. Serum lipids were measured prior to, during and after the 5-day infusion period. The percentage of cholesterol as high-density lipoproteins (HDL) fell from a mean preinfusion value of 34.7 +/- 2.8 to 27.9 +/- 2.5 (p less than 0.05), while the percentage of cholesterol as low-density lipoproteins (LDL) increased from 40.7 +/- 2.2 to 46.8 +/- 3.4 (p less than 0.05). Serum triglycerides fell significantly (p less than 0.01) from 106.2 +/- 13.7 mg/dl to 64.6 +/- 8.8 mg/dl at 3 days, being 85.3 +/- 3.7 mg/dl at 5 days. No significant change in percent cholesterol as very low-density lipoproteins (VLDL), or levels of serum total cholesterol or phospholipids occurred. Lipoprotein X was detectable in six patients after 5 days. To study triglyceride clearance 1.7 g/kg of fat emulsion was infused over 8 hr and serial blood samples obtained. Within 3 hr of stopping the fat infusion, triglyceride levels had fallen to preinfusion values.

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Citations

Jan 1, 1996·Progress in Lipid Research·A C BachA Frey
Apr 1, 1990·The Journal of Surgical Research·E C OparaO E Akwari
Aug 15, 2002·Biochemical and Biophysical Research Communications·Tohru OhamaYuji Matsuzawa
Jul 24, 2015·Domestic Animal Endocrinology·H AkbariR C Boston
Aug 18, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Manpreet S MundiSara Bonnes
Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·M Salo
May 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·J M JacksonH A Lee
Feb 14, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Manpreet S MundiRyan T Hurt
Sep 25, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Manpreet S MundiRyan T Hurt

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