Abstract
The effect of short-term infusion of intravenous fat on serum lipids was assessed in 23 patients who had elective cancer operations and were given 20% Intralipid for 5 days postoperatively as part of a standard total parenteral nutrition regimen. Serum lipids were measured prior to, during and after the 5-day infusion period. The percentage of cholesterol as high-density lipoproteins (HDL) fell from a mean preinfusion value of 34.7 +/- 2.8 to 27.9 +/- 2.5 (p less than 0.05), while the percentage of cholesterol as low-density lipoproteins (LDL) increased from 40.7 +/- 2.2 to 46.8 +/- 3.4 (p less than 0.05). Serum triglycerides fell significantly (p less than 0.01) from 106.2 +/- 13.7 mg/dl to 64.6 +/- 8.8 mg/dl at 3 days, being 85.3 +/- 3.7 mg/dl at 5 days. No significant change in percent cholesterol as very low-density lipoproteins (VLDL), or levels of serum total cholesterol or phospholipids occurred. Lipoprotein X was detectable in six patients after 5 days. To study triglyceride clearance 1.7 g/kg of fat emulsion was infused over 8 hr and serial blood samples obtained. Within 3 hr of stopping the fat infusion, triglyceride levels had fallen to preinfusion values.
References
Nov 1, 1978·Anaesthesia and Intensive Care·J C GibsonL Barton
May 1, 1979·JPEN. Journal of Parenteral and Enteral Nutrition·C W Van WayC Dresler
Dec 1, 1975·Annals of Internal Medicine·M C RiellaB H Scribner
May 1, 1977·The American Journal of Medicine·T GordonT R Dawber
Dec 1, 1978·Annals of Internal Medicine·D StrejaP O Kwiterovich
Dec 1, 1979·The Journal of Clinical Investigation·E GriffinA Angel
Mar 1, 1976·The American Journal of Clinical Nutrition·J W BroviacB H Scribner
Sep 1, 1976·The American Journal of Clinical Nutrition·C R FlemingR E Hodges
Mar 10, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Ritland, E Gjone
Jan 1, 1986·Critical Care Medicine·M M MeguidW G Hammond
Oct 1, 1986·The Surgical Clinics of North America·M Kurzer, M M Meguid
Jan 1, 1985·Pediatric Research·H ZaidanP Hamosh
Jul 1, 1969·The Journal of Clinical Investigation·D SeidelR H Furman
Jul 23, 1983·Lancet·M M MeguidJ J Terz
Nov 1, 1983·JPEN. Journal of Parenteral and Enteral Nutrition·D S McLaren, M M Meguid
Sep 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·D RigaudS Bonfils
Nov 1, 1984·Archives of Surgery·M M MeguidW G Hammond
Dec 1, 1984·Archives of Surgery·W C AbbottG L Blackburn
Apr 1, 1981·The Journal of Pediatrics·R DhanireddyP Hamosh
Oct 1, 1982·The Journal of Pediatrics·H ZaidanP Hamosh
Jul 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·M M MeguidD C Nabseth
Dec 1, 1918·Proceedings of the National Academy of Sciences of the United States of America·J A Harris, F G Benedict
Citations
Jan 1, 1996·Progress in Lipid Research·A C BachA Frey
May 1, 1996·Nutrition·T C BallardE C Opara
Apr 1, 1990·The Journal of Surgical Research·E C OparaO E Akwari
Apr 1, 1992·The Journal of Surgical Research·M GarfinkelO E Akwari
Aug 15, 2002·Biochemical and Biophysical Research Communications·Tohru OhamaYuji Matsuzawa
Jul 24, 2015·Domestic Animal Endocrinology·H AkbariR C Boston
Aug 18, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Manpreet S MundiSara Bonnes
Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·M Salo
May 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·J M JacksonH A Lee
Jan 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·M Gerard-BoncompainD Robert
Feb 14, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Manpreet S MundiRyan T Hurt
Sep 25, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Manpreet S MundiRyan T Hurt
May 25, 2021·Food Science & Nutrition·Changsheng LiuFang Wang