PMID: 9423902Jan 10, 1998Paper

Short-term effects of flurbiprofen and diclofenac on refractive outcome and corneal haze after photorefractive keratectomy

Journal of Cataract and Refractive Surgery
S H BaekJ H Lee

Abstract

To evaluate the short-term effects of topical nonsteroidal anti-inflammatory drugs (NSAIDs) on refractive outcome and corneal haze after excimer laser photorefractive keratectomy (PRK) according to the degree of myopia and to compare the results with those of topical steroids. Seoul National University Hospital, Seoul, Korea. Patients were divided into two groups: low to moderate myopia (-6.00 diopters [D] or less) and high myopia (greater than 6.00 D). Then, each patient was randomly assigned to one of three drug subgroups for initial management (4 months post-PRK): corticosteroids (fluorometholone 0.1%); flurbiprofen sodium 0.03% (Ocufen); diclofenac sodium 0.1% (Decrol). Follow-up was 6 months. In eyes with low to moderate myopia, the steroid and diclofenac subgroups had significantly different refractions 2 and 4 months postoperatively but no difference at 6 months; subjective haze grading was consistently lower in the steroid subgroup than in the NSAID subgroups (flurbiprofen, diclofenac) after 2 months. In eyes with high myopia, the steroid subgroup had significantly less myopic regression after 3 weeks and lower subjective haze after 2 months than the NSAID subgroups. The steroid subgroup had severe myopic regression or ...Continue Reading

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Citations

Sep 29, 2000·Cornea·R D StultingJ D Carr
Apr 21, 2004·Cornea·Naazli M ShaikhStephen C Kaufman
Sep 17, 2002·Journal of Cataract and Refractive Surgery·Federico Castro-MuñozledoWalid Kuri-Harcuch
Mar 17, 2011·Journal of Cataract and Refractive Surgery·Chyong Jy NienJames V Jester
May 11, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Martina ScholzUwe Pleyer
Mar 14, 2000·Journal of Cataract and Refractive Surgery·P Fagerholm
Apr 10, 2020·Journal of Cataract and Refractive Surgery·Mojgan PakbinHassan Hashemi
Jun 13, 2002·Acta Ophthalmologica Scandinavica·Heather C Baldwin, John Marshall

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