Short-term effects of high-dose zoledronic acid treatment on bone mineralization density distribution after orthotopic liver transplantation.

Calcified Tissue International
Barbara M MisofK Klaushofer

Abstract

Patients with "hepatic" bone disease exhibit increased fracture incidence. The effects on bone material properties, their changes due to orthotopic liver transplantation (OLT), as well as zolendronate (ZOL) treatment have not yet been investigated. We studied bone mineralization density distribution (BMDD) in paired transiliacal biopsies (at and 6 months after OLT) from patients (control CON n = 18, treatment group ZOL n = 21, the latter treated with i.v. ZOL at doses of 4 mg/month) for how bone at the material level was affected by the "hepatic" disease in general, as well as by OLT and ZOL in particular. (1) BMDD parameters at baseline reflected disturbed bone matrix mineralization in "hepatic" bone disease combined with low turnover. Trabecular bone displayed a decrease in mean and most frequent calcium concentration (Ca(MEAN) -2.9% and Ca(PEAK) -2.8%, respectively; both P < 0.001), increased heterogeneity of mineralization (Ca(WIDTH) +12.2%, P = 0.01), and increased percentage of bone areas with low mineralization (Ca(LOW) +32.4%, P = 0.02) compared to normal; however, there were no differences compared to cortical bone. (2) Six months after OLT, ZOL-treated trabecular bone displayed reduced Ca(LOW) (-32.0%, P = 0.047), cor...Continue Reading

References

Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E HayN F LaRusso
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A McDonaldG W McCaughan
May 1, 1989·Calcified Tissue International·G L KleinL J Deftos
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jan 1, 1983·Metabolic Bone Disease & Related Research·A Boyde, S J Jones
Feb 5, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S VediJ E Compston
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T MashibaD B Burr
Aug 25, 2000·Journal of Women's Health & Gender-based Medicine·E Siris
Jul 12, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A MonegalJ Muñoz-Gómez
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maureen M J GuichelaarJ Eileen Hay
Mar 13, 2003·Kidney International·Martin HaasRainer Oberbauer
May 24, 2003·Journal of Hepatology·J Eileen Hay
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maureen M J GuichelaarJ Eileen Hay
Apr 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maureen M J GuichelaarJ Eileen Hay
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Adi CohenElizabeth Shane
Mar 24, 2005·The Journal of Clinical Endocrinology and Metabolism·Marcella A DonovanElizabeth Shane
Jul 22, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gunda MillonigWolfgang Vogel
Feb 24, 2006·Annals of Internal Medicine·Bronwyn A L CrawfordGeoffrey W McCaughan
Jul 4, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ruth ZoehrerKlaus Klaushofer
Aug 26, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maureen M J GuichelaarJ Eileen Hay
Nov 30, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Bronwyn A CrawfordGeoffrey W McCaughan
Feb 3, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul RoschgerKlaus Klaushofer
May 4, 2007·The New England Journal of Medicine·Dennis M BlackUNKNOWN HORIZON Pivotal Fracture Trial
May 22, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M BodingbauerF Mühlbacher
Sep 20, 2007·The New England Journal of Medicine·Kenneth W LylesUNKNOWN HORIZON Recurrent Fracture Trial
Sep 26, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robert R ReckerErik F Eriksen
Nov 8, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peter R Ebeling, David B Burr
Dec 22, 2007·Bone·P RoschgerK Klaushofer
Jul 11, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Barbara M MisofKlaus Klaushofer

❮ Previous
Next ❯

Citations

Dec 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y BalaG Boivin
Mar 10, 2011·QJM : Monthly Journal of the Association of Physicians·M O PremaorJ E Compston
Sep 15, 2012·The Journal of Craniofacial Surgery·Alexis DonneysSteven R Buchman
Jun 22, 2012·Journal of Postgraduate Medicine·T BandgarN Shah
Apr 10, 2012·Gastroenterología y hepatología·Núria Guañabens, Albert Parés
May 7, 2011·Clinics and Research in Hepatology and Gastroenterology·Núria Guañabens, Albert Parés
Oct 20, 2010·Gastroenterology·Paul AnguloAlvaro Koch
Nov 26, 2010·Transplantation Proceedings·A B KarabulutO Otlu
Jun 12, 2010·Archives of Biochemistry and Biophysics·Núria Guañabens, Albert Parés
Jul 21, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sonja GamsjaegerEleftherios P Paschalis
Apr 7, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Sonsoles GuadalixFederico Hawkins
Oct 10, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Barbara M MisofKlaus Klaushofer
Jul 9, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Barbara M MisofHeinrich Resch
Jul 25, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Martin BodingbauerRainer Oberbauer
Mar 10, 2016·Arquivos De Gastroenterologia·Paulo Lisboa BittencourtPatrícia Oliveira
Dec 25, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Anitha Yadav, Elizabeth J Carey
Feb 27, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Núria Guañabens, Albert Parés
Nov 15, 2016·BioMed Research International·Lívia Alves Amaral Santos, Fernando Gomes Romeiro
Sep 5, 2019·International Journal of Molecular Sciences·Hae Min Jeong, Dong Joon Kim
Aug 24, 2021·Transplantation Proceedings·Erika Faride Rodríguez-AguilarIgnacio García-Juárez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.