Short term effects of hypertonic saline during severe sepsis and septic shock

Annales Françaises D'anesthèsie Et De Rèanimation
L MullerJ-J Eledjam

Abstract

Assessment of haemodynamic effects of 250 ml hypertonic saline 7.5% (HS) perfusion in critically ill patients with severe sepsis or septic shock. Observational study. Twelve mechanically ventilated patients with severe sepsis or septic shock requiring a pulmonary artery catheter and volume loading. Two hundred and fifty millilitres HS were given over 15 min. Were measured: heart rate (HR), mean arterial pressure (MAP) and pulmonary artery pressure (MPAP), pulmonary capillary wedge pressure (PCWP), right atrial pressure (RAP), cardiac index (CI), indexed systemic vascular resistance (ISVR), indexed pulmonary vascular resistance (IPVR), plasma sodium, chloride, protein and haemoglobin concentrations and arterial blood lactate. Studied parameters were assessed at baseline (T(0)) and 5 (T(0)) and 105 min (T(120)) after the end of HS infusion. MAP, HR and RAP were not altered. HS increased PAPM (25 +/- 5-30 +/- 6 mmHg), PCWP (13 +/- 3-18 +/- 4 mmHg) and CI (3.5 +/- 1.2-4.6 +/- 1.1 l/min per m(2)) at T(20) (P < 0.05). ISVR and IPVR were decreased at T(20). Protein and haemoglobin were decreased at T(20). Sodium and chloride were increased at T(20) (from 136 +/- 4 to 147 +/- 4 and from 110 +/- 6 to 123 +/- 6 mmol/l, respectively, P < ...Continue Reading

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Citations

Jan 26, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·N LibertG Mion
Jan 16, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·P MicheletJ-P Auffray
May 9, 2008·Emergency Medicine Australasia : EMA·Colin J Banks, Jeremy S Furyk
Apr 25, 2007·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Anthony T W CheungRobert A Gunther
Mar 5, 2019·Anesthesia and Analgesia·Diego OrbegozoFuhong Su
May 17, 2019·Anesthesia and Analgesia·Diego OrbegozoFuhong Su

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