Short-term effects of low-concentration atropine eye drops on pupil size and accommodation in young adult subjects

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Hakan KaymakFrank Schaeffel

Abstract

A single eye drop containing 0.01% atropine every evening has previously been found to inhibit myopia progression in young adults. We have tested the short-term effects of very low-dose atropine eye drops on pupil sizes and accommodation in young adult subjects. Fourteen eyes of young adult subjects participated in the clinical observation. A single eye drop was applied with concentrations of either 0.01%, 0.005%, or 0.001% in the evening. Baseline parameters were measured before atropine application. Changes of pupil sizes, under photopic and mesopic conditions, as well as accommodation amplitudes were observed over the next day and analyzed by paired the Wilcoxon signed-rank test. The pupil was significantly dilated 12 h after instillation of 0.01% atropine eye drops, both under photopic (3.3 ± 0.5 mm vs. 4.9 ± 0.9 mm) and mesopic (4.8 ± 0.7 mm vs. 6.1 ± 0.7 mm) conditions. Pupil sizes recovered over the day but were still significantly larger in the evening, compared to the baseline parameters measured on the day before (3.9 ± 0.5 mm vs. 5.3 ± 0.6 mm). The subjective near point of accommodation was reduced from 8.0 ± 2.4 to 6.6 ± 2.8 dpt in the morning and to 7.0 ± 2.9 dpt in the evening. At 0.005%, the pattern of results re...Continue Reading

References

Apr 30, 2002·Brain Research. Developmental Brain Research·Kirstan A VesseyNeville A McBrien
Oct 27, 2005·Investigative Ophthalmology & Visual Science·Earl L SmithLi-Fang Hung
Nov 15, 2006·Experimental Eye Research·Sigrid DietherAnne-Ulrike Trendelenburg
Jul 27, 2007·Investigative Ophthalmology & Visual Science·Lisa A JonesKarla Zadnik
Apr 17, 2008·Archives of Ophthalmology·Kathryn A RoseSeang-Mei Saw
Dec 17, 2009·Archives of Ophthalmology·Susan VitaleFrederick L Ferris
Dec 14, 2011·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Carly Siu-Yin LamLily Yee-Lai Chan
Oct 13, 2012·Investigative Ophthalmology & Visual Science·Jing SunXianqun Fan
May 15, 2013·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Neville A McBrienBrittany Carr
Dec 10, 2013·American Journal of Ophthalmology·Audrey ChiaDonald Tan
Jun 21, 2014·Ophthalmology·Alireza MirshahiNorbert Pfeiffer
Mar 20, 2015·Nature·Elie Dolgin
Aug 19, 2015·International Journal of Medical Sciences·Li-Juan WuWei Wang
Oct 30, 2015·Eye & Contact Lens·Jeffrey J Walline
Jan 16, 2016·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Brien A HoldenSerge Resnikoff
Jan 24, 2016·Ophthalmology·Ian G Morgan, Mingguang He
Feb 24, 2016·The British Journal of Ophthalmology·James Loughman, D I Flitcroft
Apr 27, 2017·Scientific Reports·Brittany J Carr, William K Stell
Jul 29, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Padmaja Sankaridurg
Sep 28, 2017·Progress in Retinal and Eye Research·Ian G MorganKathryn A Rose

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Citations

Aug 6, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Augustine N Nti, David A Berntsen
Apr 16, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Steffen Schmitz-ValckenbergHans Hoerauf
Sep 8, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Beata P Sander
Nov 26, 2021·Seminars in Ophthalmology·Efthymia ProusaliAsimina Mataftsi
Jan 29, 2022·European Journal of Ophthalmology·Dimitrios SoulisDimitrios Triantafyllou

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