PMID: 9426032Jan 13, 1998Paper

Short-term effects of transdermal estrogen replacement therapy on coronary vascular reactivity in postmenopausal women with angina pectoris and normal results on coronary angiograms

Journal of the American College of Cardiology
M RoquéG Sanz

Abstract

This study sought to analyze the effect of short-term transdermal estradiol treatment on in vivo coronary endothelial function in postmenopausal women with angina and normal results on coronary arteriograms. The incidence of coronary heart disease increases in women after menopause. Estrogen replacement therapy has been associated with a global reduction in cardiovascular disease incidence and mortality. In addition, coronary endothelial dysfunction has been demonstrated in a group of postmenopausal women. It has been shown that intravenous or intracoronary estrogens improve endothelial function in postmenopausal women with coronary atherosclerosis. However, the efficacy of this treatment is unknown in patients with angina and normal coronary arteries. Endothelium-dependent coronary reactivity was analyzed in 15 postmenopausal women with angina and normal coronary arteries at baseline and after 24 h of estradiol transdermal administration (100 microg). Estradiol concentration increased from 22 +/- 8 pg/ml (mean +/- SEM) at baseline to 76 +/- 13 pg/ml (p < 0.01) at 24 h. At baseline, acetylcholine induced vasoconstriction, with a mean diameter reduction of -23 +/- 6% (p = 0.002). After estrogen treatment, there was no vasoconstr...Continue Reading

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T HayashiG Chaudhuri
Apr 10, 1991·JAMA : the Journal of the American Medical Association·E Barrett-Connor, T L Bush
Jun 1, 1988·The American Journal of Cardiology·R O Cannon, S E Epstein
Nov 15, 1995·Journal of the American College of Cardiology·S A Samaan, M H Crawford
Feb 1, 1995·The American Journal of Cardiology·D M GilliganR O Cannon
Dec 15, 1994·Annals of Internal Medicine·E H LiebermanM A Creager
Oct 1, 1993·Circulation·E D EakerM Winston
May 15, 1996·American Journal of Epidemiology·K A MatthewsP Plantinga
Feb 1, 1996·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S Gupta, J Rymer
Nov 15, 1996·Journal of the American College of Cardiology·G M RosanoP A Poole-Wilson

❮ Previous
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Citations

Jun 22, 1999·Clinical Cardiology·J L Furgerson
Apr 27, 2010·Journal of Thrombosis and Thrombolysis·Lynn NugentC Noel Bairey Merz
Dec 21, 2000·Current Atherosclerosis Reports·L Mosca
Sep 16, 2010·Current Treatment Options in Cardiovascular Medicine·Arang SamimC Noel Bairey Merz
Aug 12, 1999·European Journal of Pharmacology·H BultK E Matthys
Oct 5, 2001·Journal of the American College of Cardiology·M ImamuraC Tei
Dec 12, 2001·Journal of the American College of Cardiology·P Voci, F Pizzuto
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Jul 2, 2002·The American Journal of Geriatric Cardiology·Marian C Limacher
Nov 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Junko MashibaKenji Sunagawa
Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·E Z FismanA Pines
Mar 21, 2012·The Canadian Journal of Cardiology·Armen Parsyan, Louise Pilote
May 24, 2011·Revista española de cardiología·Mercè RoquéMagdalena Duran
Mar 1, 2005·European Journal of Clinical Investigation·M SakamotoM Sata
Feb 12, 2009·Cardiovascular Therapeutics·Tiong K LimChim C Lang
Feb 9, 2010·International Journal of Cardiology·Mukesh SinghSandeep Khosla
Jul 11, 2006·The American Journal of Medicine·Todd HurstChristopher P Appleton
Apr 17, 2001·American Journal of Obstetrics and Gynecology·R A Wild, S E Reis
Oct 17, 2008·Journal of cardiology·Hiroaki Shimokawa, Satoshi Yasuda
Jul 18, 2016·International Journal of Cardiology·Petr A Sarapultsev, Alexey P Sarapultsev
May 6, 2005·The Journal of Clinical Endocrinology and Metabolism·Eija KellokoskiSohvi Hörkkö
Nov 13, 1998·Current Opinion in Lipidology·P S Bachorik
Feb 5, 2000·Journal of Applied Physiology·M R RinderA A Ehsani
Feb 22, 2001·American Journal of Physiology. Renal Physiology·R K Dubey, E K Jackson
Sep 25, 2003·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·R G V SmoldersP Kenemans
May 12, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Juan Carlos KaskiJuan Cosín-Sales
Jun 5, 1998·Journal of Women's Health·W D Schlaff

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