Short term efficacy and safety in glaucoma patients changed to the latanoprost 0.005%/timolol maleate 0.5% fixed combination from monotherapies and adjunctive therapies

The British Journal of Ophthalmology
T HamacherW C Stewart

Abstract

To evaluate efficacy and safety in patients with ocular hypertension or open angle glaucoma changed to latanoprost/timolol fixed combination (LTFC). A prospective, multicentre, historical control in which qualified patients had their previous therapy substituted by LTFC and were followed for at least 2 months. In 1676 patients LTFC was continued in 93% throughout the observation period. In all patients LTFC reduced the intraocular pressure (IOP) from 20.6 (SD 3.8) to 17.7 (3.0) mm Hg (p<0.001) compared to previous monotherapies including latanoprost, timolol, alpha agonists or carbonic anhydrase inhibitors (CAI). LTFC provided more efficacy after changing from adjunctive therapies including: a beta blocker added to either CAI, alpha agonist, or pilocarpine, or CAI added to an alpha agonist, or latanoprost added to either CAI, alpha agonist, or beta blocker (unfixed combination), and travoprost added to timolol (p<0.007). LTFC was as effective as latanoprost used with dorzolamide/timolol fixed combination (-0.9 mm Hg, p = 0.1792). The most common reason to discontinue therapy was lack of efficacy (n = 70, 4%) and adverse event (n = 17, 1%). In a clinical setting, patients who have their monotherapy or adjunctive therapy substitu...Continue Reading

References

Sep 1, 1996·Clinical Cardiology·W C Stewart, W P Castelli
Jul 6, 2002·Archives of Ophthalmology·Eve J HigginbothamUNKNOWN Fixed Combination Investigative Group
Mar 17, 2004·Ophthalmology·Dong H ShinUNKNOWN Fixed Combination Latanoprost/Timolol Study Group

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Citations

Jun 15, 2007·Advances in Therapy·Stephan DunkerUNKNOWN Latanoprost/Timolol Fixed Combination Study Group
Oct 21, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kenji InoueGoji Tomita
Jun 29, 2013·Expert Opinion on Pharmacotherapy·Anastasios Gp KonstasMurat Irkec
Dec 22, 2006·Expert Opinion on Drug Safety·Gábor Holló
Mar 22, 2013·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Glenis J CraneJonathan D Karnon
Sep 30, 2009·European Journal of Ophthalmology·William C StewartHeather M Mathis

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