PMID: 8459199Feb 1, 1993Paper

Short-term endocrine consequences of total body irradiation and bone marrow transplantation in children treated for leukemia

The Journal of Endocrinology
M RyallsC G Brook

Abstract

We studied 24-h hormone profiles and hormonal responses to insulin-induced hypoglycaemia prospectively in 23 children of similar age and pubertal stage, nine of whom had received prior cranial irradiation (group 1) and fourteen of whom had not (group 2), before and 6-12 months after total body irradiation (TBI) for bone marrow transplantation in leukaemia. Fourier transformation demonstrated that group 1 children had a faster periodicity of GH secretion before TBI than group 2 children (160 vs 200 min) but the amplitude of their GH peaks was similar. There were no differences between the groups in circadian cortisol rhythm, serum concentrations of insulin-like growth factor-I (IGF-I), sex steroids and basal thyroxine (T4). The peak serum GH concentrations observed after insulin-induced hypoglycaemia were similar between the two groups but the majority of patients had blunted responses. TBI increased the periodicity of GH secretion in both groups (group 1 vs group 2; 140 vs 180 min), but the tendency to attenuation of amplitude was not significant. There were no significant changes in the peak serum GH concentration response to insulin-induced hypoglycaemia which remained blunted. Serum IGF-I, sex steroid, cortisol or T4 concent...Continue Reading

Citations

Mar 2, 2006·Pituitary·Ken H Darzy, Stephen M Shalet
Feb 14, 2008·Pituitary·Ken H Darzy, Stephen M Shalet
Oct 1, 1996·The Journal of Pediatrics·A Clement-De BoersJ M Vossen
Aug 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Helen A Spoudeas
Mar 6, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Y BelkacémiM Ozsahin
Apr 1, 1995·Clinical Endocrinology·S M ShaletM D Donaldson
Feb 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Ken H DarzyStephen M Shalet

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