Short-term exercise training enhances reflex cholinergic nitric oxide-dependent coronary vasodilation in conscious dogs

Circulation Research
G ZhaoT H Hintze

Abstract

The effects of exercise training on the coronary vasodilation following activation of the Bezold-Jarisch reflex were examined in conscious dogs. Mongrel dogs were chronically instrumented using sterile techniques for measurements of systemic hemodynamics and left circumflex coronary blood flow (CBF). With the heart rate controlled (150 bpm), veratrine (0.5 to 20 micrograms/kg) caused dose-dependent increases in CBF; eg, 5 micrograms/kg of veratrine increased CBF by 61 +/- 6% from 31 +/- 1.3 mL/min (P < .05). After exercise training, the dose-response curve of CBF in response to veratrine was shifted to the left; eg, 5 micrograms/kg of veratrine increased CBF by 101 +/- 12% (P < .05 compared with control) from 34 +/- 2.3 mL/min. The enhanced coronary vasodilation was blunted by nitro-L-arginine (NLA, 35 mg/kg). In anesthetized dogs after exercise training, electrical stimulation of the left vagus nerve caused greater increases in CBF, and NLA inhibited increases in CBF. Acetylcholine, norepinephrine, angiotensin II, and bradykinin caused greater increases in NO2- production in coronary microvessels from exercise-trained dogs compared with those from normal dogs. Our results indicate that the coronary vasodilation following activ...Continue Reading

References

Oct 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H L Wyatt, J Mitchell
Oct 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M H LaughlinC M Tipton
Jan 1, 1989·Journal of Applied Physiology·S E DiCarloH L Stone
Mar 1, 1985·Progress in Cardiovascular Diseases·T F Schaible, J Scheuer
Sep 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·I Y Liang, H L Stone
Dec 17, 1981·The New England Journal of Medicine·D M KramschW B Hood
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Sep 1, 1993·Journal of Applied Physiology·M D DelpM H Laughlin

❮ Previous
Next ❯

Citations

Apr 25, 2000·Clinical and Experimental Pharmacology & Physiology·B A Kingwell
Dec 17, 2009·Circulation Research·Nobuhiro SuematsuThomas H Hintze
Aug 17, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A SammanA Ignaszewski
Apr 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey G WilliamsThomas H Hintze
Sep 7, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B A Kingwell
Feb 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Josef NiebauerJohn P Cooke
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S MitalT H Hintze
Jul 17, 1999·The American Journal of Physiology·G ZhaoT H Hintze

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.