Short term exposure to di-n-butyl phthalate (DBP) disrupts ovarian function in young CD-1 mice

Reproductive Toxicology
Nivedita SenZelieann R Craig

Abstract

Di-n-butyl phthalate (DBP) is present in many beauty and medical products. Human exposure estimates range from 0.007-0.01 mg/kg/day in the general population and up to 0.233 mg/kg/day in patients taking DBP-coated medications. Levels of phthalates tend to be higher in women, thus, evaluating ovarian effects of DBP exposure is of great importance. Mice were given corn oil (vehicle) or DBP at 0.01, 0.1, and 1000 mg/kg/day (high dose) for 10 days to test whether DBP causes ovarian toxicity. Estrous cyclicity, steroidogenesis, ovarian morphology, and apoptosis and steroidogenesis gene expression were evaluated. DBP exposure decreased serum E2 at all doses, while 0.1DBP increased FSH, decreased antral follicle numbers, and increased mRNA encoding pro-apoptotic genes (Bax, Bad, Bid). Interestingly, mRNAs encoding the steroidogenic enzymes Hsd17b1, Cyp17a1 and Cyp19a1 were increased in all DBP-treated groups. These novel findings show that DBP can disrupt ovarian function in mice at doses relevant to humans.

References

Jul 1, 1992·Calcified Tissue International·A C Bagur, C A Mautalen
Apr 1, 1987·Toxicology and Applied Pharmacology·J C LambJ R Reel
May 21, 1999·Archives of Internal Medicine·F B HuM J Stampfer
Dec 1, 1999·The Journal of Nervous and Mental Disease·L DennersteinE Dudley
Jun 1, 1961·The Anatomical Record·A D DIXON
May 14, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kim P LehmannKevin W Gaido
Jul 23, 2004·Biology of Reproduction·Kara L BrittJock K Findlay
Feb 24, 2006·The Journal of Reproduction and Development·Hwi-Cheul LeeMasugi Nishihara
Jun 10, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Leon Earl GrayJoseph Ostby
Mar 8, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jerome M GoldmanRalph L Cooper
May 8, 2007·Archives of Biochemistry and Biophysics·Kaname Kawajiri, Yoshiaki Fujii-Kuriyama
Oct 17, 2008·Journal of Toxicology and Environmental Health. Part a·Ju Young RyuHyung Sik Kim
Nov 4, 2008·Biochemical Pharmacology·Isabel Hernández-OchoaJodi A Flaws
Mar 10, 2009·Environmental Health Perspectives·Sonia Hernández-DíazRuss Hauser
Dec 17, 2009·Journal of Exposure Science & Environmental Epidemiology·Cynthia J HinesAntonia M Calafat
Jan 27, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kamin J JohnsonJessie Q Xia
Jul 13, 2011·Toxicology and Applied Pharmacology·Susan Y EulingKevin W Gaido
Mar 16, 2012·Endocrine Reviews·Laura N VandenbergJohn Peterson Myers
Jul 4, 2012·Regulatory Toxicology and Pharmacology : RTP·Lorenz R Rhomberg, Julie E Goodman
Feb 15, 2013·Critical Reviews in Toxicology·Vanessa R KayWarren G Foster
Jul 9, 2013·Toxicology and Industrial Health·Rahish AhmadSunil Kumar

❮ Previous
Next ❯

Citations

Nov 21, 2016·Journal of Applied Toxicology : JAT·Lindsay M RasmussenZelieann R Craig
Jan 20, 2016·PloS One·Jia-Qing ZhangBao-Song Xing
Dec 28, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Zelieann R Craig, Ayelet Ziv-Gal
Oct 4, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michal AdirRonit Machtinger
Nov 18, 2018·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Huawei ZhangHong Wang
Apr 9, 2017·Environmental Health : a Global Access Science Source·Pauline VabreRoger D Leandri
Sep 16, 2017·Archives of Environmental Contamination and Toxicology·Guanying WangJianpeng Gao
Sep 24, 2020·International Journal of Environmental Research and Public Health·Henrieta HlisníkováAlexander Sirotkin
Oct 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Sung Hoon KimByung Moon Kang
Jan 21, 2020·Data in Brief·Maricarmen Colón-DíazZelieann R Craig
Jan 19, 2021·Pharmacological Reports : PR·Henrieta HlisníkováAlexander Sirotkin
Apr 21, 2021·Current Medical Science·Hua-Hua JiangYu-Feng Li
Jul 10, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Eleftheria M PanagiotouPauliina Damdimopoulou
Jun 28, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Estela J JaureguiZelieann R Craig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis