Short-term exposure to formaldehyde promotes oxidative damage and inflammation in the trachea and diaphragm muscle of adult rats

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
Luiza Fagundes LimaFrank Silva Bezerra

Abstract

Formaldehyde (FA) is an environmental pollutant widely used in industry. Exposure to FA causes irritation of the respiratory mucosa and is associated with inflammation and oxidative stress in the airways. This study aimed at investigating the oxidative effects on the inflammatory response in the trachea and the diaphragm muscle (DM) of rats exposed to different concentrations of formaldehyde. Twenty-eight Fischer male rats were divided into four groups: control group (CG) exposed to the ambient air; and three groups exposed to the following formaldehyde concentrations of 1% (FA1), 5% (FA5) and 10% (FA10), respectively. The exposure occurred for twenty minutes, three times a day for five days. Oxidative stress analyses were performed by carbonyl protein, lipid peroxidation and catalase activity. The assessment of inflammatory cell influx in both organs and the mucus production in the trachea was carried out. There was an increase of lipid peroxidation in the trachea and the DM of FA1 and FA5 groups compared to the CG and FA10. The oxidation of DM proteins increased in FA10 group compared to CG, FA1 and FA5. The catalase enzyme activity in the DM was reduced in FA1, FA5 and FA10 compared to the CG. Meanwhile, there was a reductio...Continue Reading

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Citations

Jan 18, 2016·Environmental Pollution·Giselle Luciane MurtaFrank Silva Bezerra
May 23, 2016·Archives of Toxicology·Gunnar Damgård NielsenPeder Wolkoff
Nov 8, 2016·Immunopharmacology and Immunotoxicology·Jiaying ChengZhenhai Li
Apr 4, 2018·Genes·Junhui GuoLuoping Zhang
Sep 1, 2017·Toxicology and Industrial Health·Thais Lourenço MartinsFrank Silva Bezerra
Feb 19, 2020·Experimental Lung Research·Erika Tiemi KozimaFrank Silva Bezerra
Jul 21, 2020·Drug and Chemical Toxicology·Letícia BernardiniNatália Brucker
May 31, 2017·BioMed Research International·Min XuCheng Lv
Feb 11, 2021·Journal of Occupational Medicine and Toxicology·Federica GhelliRoberto Bono
May 12, 2021·Journal of Cellular and Molecular Medicine·Ying ZhangZhirong Jiang

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